Special Issue "Functional Defects of Keratinocytes in Inflammatory Skin Diseases"
Deadline for manuscript submissions: 31 August 2021.
Interests: cell biology; apoptosis; keratinocytes; keratinocytes differentiation; keratinocytes proliferation; notch signaling; dermatology diseases
Interests: Immunology; clinical pathology; molecular genetics; molecular biology; OMICs; bioinformatics
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In addition to providing physical, chemical and biological protection against the external environment, the skin barrier is important for maintaining homeostasis by preventing an excessive loss of water, ions and serum proteins.
Keratinocytes are the main cell type of the epidermis and originate in the basal layer, in which keratinocytes are mitotically active; then, they progressively differentiate and migrate upwards to the stratum corneum. Moreover, keratinocytes actively contribute in the cutaneous immune responses producing a plethora of inflammatory mediators.
Defects in keratinocytes differentiation, proliferation and inflammation are closely related to many inflammatory skin diseases, such as Hidradenitis Suppurativa, Psoriasis, Atopic Dermatitis and Behçet disease.
In this context, Notch signaling plays a key role mediating the normal keratinocytes turnover. Notch signaling controls the induction of keratinocytes growth, promotes activation of the differentiation program, and also it is involved in the regulation of inflammatory responses. Alterations of Notch signaling can induce a failure in the regulation of keratinocytes functions, which in turn produces skin diseases.
This Special Issue is dedicated to the role of keratinocytes in skin diseases. Areas of particular interest include, but are not limited to, keratinization and skin diseases, autoinflammatory keratinization diseases, and Notch signaling regulation in skin diseases.
Dr. Paola Maura Ticarico
Prof. Dr. Sergio Crovella
Manuscript Submission Information
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- dermatological diseases
- notch signaling