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Special Issue "Functional Defects of Keratinocytes in Inflammatory Skin Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editors

Dr. Paola Maura Ticarico
E-Mail Website
Guest Editor
Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell’Istria 65/1, 34137 Trieste, Italy
Interests: cell biology; apoptosis; keratinocytes; keratinocytes differentiation; keratinocytes proliferation; notch signaling; dermatology diseases
Prof. Dr. Sergio Crovella
E-Mail Website
Co-Guest Editor
Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar
Interests: Immunology; clinical pathology; molecular genetics; molecular biology; OMICs; bioinformatics
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In addition to providing physical, chemical and biological protection against the external environment, the skin barrier is important for maintaining homeostasis by preventing an excessive loss of water, ions and serum proteins.

Keratinocytes are the main cell type of the epidermis and originate in the basal layer, in which keratinocytes are mitotically active; then, they progressively differentiate and migrate upwards to the stratum corneum. Moreover, keratinocytes actively contribute in the cutaneous immune responses producing a plethora of inflammatory mediators.

Defects in keratinocytes differentiation, proliferation and inflammation are closely related to many inflammatory skin diseases, such as Hidradenitis Suppurativa, Psoriasis, Atopic Dermatitis and Behçet disease.

In this context, Notch signaling plays a key role mediating the normal keratinocytes turnover. Notch signaling controls the induction of keratinocytes growth, promotes activation of the differentiation program, and also it is involved in the regulation of inflammatory responses. Alterations of Notch signaling can induce a failure in the regulation of keratinocytes functions, which in turn produces skin diseases.

This Special Issue is dedicated to the role of keratinocytes in skin diseases. Areas of particular interest include, but are not limited to, keratinization and skin diseases, autoinflammatory keratinization diseases, and Notch signaling regulation in skin diseases.

Dr. Paola Maura Ticarico
Guest Editor
Prof. Dr. Sergio Crovella
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • dermatological diseases
  • notch signaling
  • keratinocytes
  • inflammation
  • autoinflammation
  • differentiation
  • keratinization
  • proliferation

Published Papers

This special issue is now open for submission.
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