Dear Colleagues,

Obstructive Sleep Apnea syndrome (OSAS) is a frequent condition estimated in 5%-12% of the adult population and its impact on cardiovascular risk seems to be consistent.

The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are sympathetic activity, oxidative stress and inflammation. Other affected domains include adipokines, adhesion molecules and molecules that respond to endoplasmic reticulum stress.

During the last decade significant steps towards a precision medicine approach have been taken, also in the field of sleep disorder management.

The aim of this special issue is to collect Molecular Approach on diagnostic advancements and targeted therapies outcomes of OSAS and other sleep disorders.

In particular, we are going to consider papers regarding:

Novel aspects of CPAP treatment and interventions to improve CPAP adherence;

Emerging pharmacotherapy of OSA;

Evaluation of OSA-related biomarkers

Pathogenetic mechanisms and consequences of OSA

Chronic Intermittent Hypoxia

Sleep Fragmentation

Innovative therapies for OSA treatment

We are certain of your active collaboration to create an interesting Special Issue that will help physicians to identify the most appropriate therapeutic choice for patients affected by sleep disorders

Dr. Giovanni Cammaroto
Prof. Claudio Vicini
Guest Editors

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• sleep disorders
• obstructive sleep apnea
• sleepiness health
• CPAP
• quality of life
• prevention