Special Issue "Patient-Derived Organoids in Personalized Medicine"
Deadline for manuscript submissions: 30 April 2022.
Although classical 2D cell cultures have provided a tremendous amount of data on how cancers and other diseases are established, they do not properly model the intra- and interpatient cellular heterogeneity, characteristic for the in vivo situation. In addition, some diseases are difficult to model with mouse systems. As an example, lung cancer is an extremely heterogenous disease with a wide array of mutations; thus, this variance in genetic differences is difficult to capture with mouse models. The 3D organoid technology is a promising tool to solve many of these problems; it captures much of the cellular heterogeneity of the original tissue, is genetically stable, and it represents the complex architecture of the epithelial tissue of origin well. Not surprisingly, this technology has become an invaluable tool in the study of stem cells and their niche, the effect of mutations for diseases, and in finding novel drug combinations for individual cancer patients. Despite the enormous increase in their application and popularity, their standardization is still ongoing, and in many cases maintaining organoids is quite expensive. In this Special Issue, we welcome original articles and reviews about the application of organoids in disease modelling and drug testing, in understanding the development of tissues and organs, and about methodological advancements in organoid technology.
Dr. Zoltán Wiener
Manuscript Submission Information
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