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Special Issue "Advances in Nanostructured Materials between Pharmaceutics and Biomedicine 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editors

Prof. Dr. Stefano Giovagnoli
E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, University of Perugia, 6100 Perugia, Italy
Interests: controlled release; solid state properties; organic and inorganic nano- microparticles; inhaled dry powders; drug physical modification; cell microencapsulation and engineering
Special Issues and Collections in MDPI journals
Prof. Dr. Alessandro Di Michele
E-Mail Website
Co-Guest Editor
Department of Physics and Geology, University of Perugia, Perugia, Italy
Interests: nanomaterials; sonochemistry; catalysis; electron microscopy imaging
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Nanostructured materials are materials containing an internal or surface structure in the nanometer length scale on which their properties depend. Organic, inorganic, and hybrid nanostructures find broad application across several areas of pharmaceutics and biomedicine. In particular, medicinal chemistry, drug delivery, and tissue engineering have benefited from the progress in such technologies. Considerable advances have characterized the recent application of nanostructured materials in medicine, from diagnostic biosensors to scaffolds for tissue engineering, without forgetting the high relevance in catalysis and biocatalysis applied to biology and chemical synthesis.

This Special Issue aims at the most recent advances in nanostructured material across chemistry and biology, including manufacturing and potential toxicity issues. Particular importance will be given to applications in medicinal chemistry and flow chemistry, targeted and local drug nanocarriers, nanostructured matrices for controlled release, biosensors, and functional nanomaterials and their biological relevance.

Accepted papers are published in the joint Special Issue in ijms or Pharmaceutics.(https://0-www-mdpi-com.brum.beds.ac.uk/journal/pharmaceutics/special_issues/pharm

Prof. Dr. Stefano Giovagnoli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nanostructured materials in medicinal chemistry
  • Nanomaterials and flow chemistry
  • Biofunctional nanomaterials
  • Nanostructured materials for catalysis
  • Nanostructured scaffolds for tissue engineering
  • Nanomaterials for local and targeted drug delivery
  • Nanostructured biosensors and diagnostic tools
  • Nanostructured scaffolds for biocatalysis
  • Nanostructured matrices for drug delivery
  • Nanostructured materials manufacturing
  • Nanomaterial toxicity
  • Nanomaterial functionalization and characterization
  • Nanomaterial structural analysis
  • Nanoparticles
  • Functional nanomaterials
  • Heterogenous catalysis
  • Biocatalysis
  • Flow chemistry
  • Biosensors
  • Diagnostics
  • Local and targeted drug delivery
  • Nanotoxicity
  • Nanostructured scaffolds

Published Papers (1 paper)

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Enhanced Activity and Sustained Release of Protocatechuic Acid, a Natural Antibacterial Agent, from Hybrid Nanoformulations with Zinc Oxide Nanoparticles
Int. J. Mol. Sci. 2021, 22(10), 5287; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22105287 - 18 May 2021
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Hybrid nanostructures can be developed with inorganic nanoparticles (NPs) such as zinc oxide (ZnO) and natural antibacterials. ZnO NPs can also exert antibacterial effects, and we used them here to examine their dual action in combination with a natural antibacterial agent, protocatechuic acid [...] Read more.
Hybrid nanostructures can be developed with inorganic nanoparticles (NPs) such as zinc oxide (ZnO) and natural antibacterials. ZnO NPs can also exert antibacterial effects, and we used them here to examine their dual action in combination with a natural antibacterial agent, protocatechuic acid (PCA). To produce hybrid nanoformulations, we functionalized ZnO NPs with four types of silane organic molecules and successfully linked them to PCA. Physicochemical assessment confirmed PCA content up to ~18% in hybrid nanoformulations, with a PCA entrapment efficiency of ~72%, indicating successful connection. We then investigated the in vitro release kinetics and antibacterial effects of the hybrid against Staphylococcus aureus. PCA release from hybrid nanoformulations varied with silane surface modification. Within 98 h, only 8% of the total encapsulated PCA was released, suggesting sustained long-term release. We used nanoformulation solutions collected at days 3, 5, and 7 by disc diffusion or log reduction to evaluate their antibacterial effect against S. aureus. The hybrid nanoformulation showed efficient antibacterial and bactericidal effects that also depended on the surface modification and at a lower minimum inhibition concentration compared with the separate components. A hybrid nanoformulation of the PCA prodrug and ZnO NPs offers effective sustained-release inhibition of S. aureus growth. Full article
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