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Special Issue "Biotechnology-Recent Advances"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 October 2021.

Special Issue Editors

Prof. Dr. Marek J. Łos
E-Mail Website
Guest Editor
Centre of Biotechnology, Silesian University of Technology, 44-100 Gliwice, Poland
Interests: cancer immunology; cell death execution pathways; cancer stem cell biology; epigenetic reprogramming (production of iPS-cells); transdifferentiation technologies; other aspects of regenerative pharmacology
Special Issues and Collections in MDPI journals
Prof. Dr. Wirginia Likus
E-Mail Website
Co-Guest Editor
Department of Anatomy, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland
Interests: reconstructive medicine

Special Issue Information

Dear Colleagues,

The 21st century is witnessing a rapid progress in biotechnology that will likely revolutionize medical interventions not only in the area of transplantology but also in that of drug delivery, with the identification of the most suitable cell subpopulations as primary therapeutic targets in oncology and in tissue regeneration. For example, in 2006 Yamanaka and colleagues developed a technology to produce isogenic (embryonic-like) induced pluripotent stem cells (iPSCs) from somatic cells by the process of reprogramming. iPSCs could then be differentiated into virtually any cell type in the body. In the meantime, an alternative technology of customized cell production from somatic cells through the process of transdifferentiation has progressed. Furthermore, our understanding of the biology of cancer allows for pinpointing cell populations (cancer stem cells, cancer initiating cells, cancer propagating cells) that are responsible for therapeutic failure. On the other hand, in the material science area, new composite materials (biodegradable and non-biodegradable) are being developed that may replace specific components of the connective tissue in different specialized organs. The proposed Special Issue aims to present diverse advances in biotechnology (i) at the level of cell and tissue engineering, (ii) at the level of advanced cancer therapy development, and (iii) at the level of biomaterial and general biotechnology science. Hence, it aims to bridge the gap between the above-mentioned research areas, while presenting specific aspects in an understandable manner to researchers from distinct research fields.

Prof. Dr. Marek J. Łos
Guest Editor
Prof. Dr. Wirginia Likus
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • stem cells
  • biomaterials
  • tissue engineering
  • reprogramming
  • transdifferentiation
  • electrospinning
  • 3D printing

Published Papers (1 paper)

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Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating
Int. J. Mol. Sci. 2021, 22(14), 7705; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22147705 - 19 Jul 2021
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Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation [...] Read more.
Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility. Full article
(This article belongs to the Special Issue Biotechnology-Recent Advances)
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