Special Issue "Stem Cells in Neurodegenerative Pathologies"
Deadline for manuscript submissions: 31 July 2021.
Interests: models of neurodegenerative diseases; schizophrenia and psychopathy; use of stem cells in neurodegeneration and neurodevelopment; blood-brain barrier; organ-on-chip; humanized models; identification of potential therapeutic molecules for brain diseases
Interests: neurodegeneration; mitochondrial function; inflammation; potassium channels
Special Issues and Collections in MDPI journals
Neurodegenerative diseases are characterized by the chronic and progressive loss of neuronal functions in specific brain areas, resulting in memory deficit, cognitive impairment, or impaired motor coordination. There is a wide range of hereditary and sporadic neurologic disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. All these diseases occur as a result of neurodegeneration and include typical protein misfolding and aggregation. Although intensive efforts have been made to find a cure, effective treatments for neurodegenerative diseases have not yet been discovered. Possible reasons for this include the lack of appropriate human disease models and a limited understanding of the etiological and neurobiological mechanisms of these conditions. Experimental models that accurately mimic the development of neurodegenerative diseases in humans are desperately needed to understand the cause and mechanisms of these diseases, as well as to identify new therapeutic targets. Recent advances in stem cell technology have opened the path to the generation of induced pluripotent stem cells (iPSCs) from somatic cells, thus offering an unlimited source of patient-specific disease-relevant cells for more accurate modeling. In this Special Issue, we aim to summarize the current knowledge in this important field and give researchers the possibility of sharing novel data on the multiple aspects of modeling neurodegeneration by using stem cells in different disease pathologies. We invite experts to contribute with critical reviews and research papers on, but not limited to, the neurodegenerative diseases mentioned above, describing different models and mechanisms that play a role in neurodegeneration and the use of such models in drug discovery.
Dr. Šárka Lehtonen
Dr. Amalia Dolga
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- neurodegenerative diseases
- stem cells
- cell-autonomous and non-cell-autonomous mechanism
- protein misfolding and aggregation
- humanized models
- drug discoveries