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Nutrients
Special Issues
Nutritional Supplements for Bone Health
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Nutritional Supplements for Bone Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 5 October 2024 | Viewed by 2424

Special Issue Editor

Dr. Yan Wen

E-Mail Website
Guest Editor
Key Laboratory of Trace Elements and Endemic Diseases of National Health Commission, Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Interests: bone and cartilage integrity; osteoarthropathy; Kashin–Beck disease; mycotoxin

Special Issue Information

Dear Colleagues,

Bone health is of great importance to our daily activities and is maintained using multiple nutrients under a complicated regulatory system. Nutritional supplements are developed and utilized to keep and improve our bone health under pathological status or during specific life stages. In this context, there are many issues to address. Numerous studies have focused on this topic to help improve the supplement usage strategy. We organized this Special Issue aiming to collect and spread the most current and valuable data on this topic, which we believe will eventually boost the general bone health of the public.

We are enthusiastic about your original research, no matter whether it is population-based or animal-based, in vivo or in vitro, and clinical or basic. Meanwhile, we also welcome meta-analyses and reviews in which up-to-date summaries and informative results are provided. Any other opinions from experts on this topic are more than welcome.

Dr. Yan Wen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone health
  • nutrients
  • nutritional supplements
  • bone development
  • osteochondropathy

Published Papers (2 papers)

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Research

14 pages, 2460 KiB  
Article
A Metabolomics Study of Feces Revealed That a Disturbance of Selenium-Centered Metabolic Bioprocess Was Involved in Kashin–Beck Disease, an Osteoarthropathy Endemic to China
by Yan Wen, Bingyi Wang, Panxing Shi, Xiaoge Chu, Sirong Shi, Yao Yao, Lu Zhang and Feng Zhang
Nutrients 2023, 15(21), 4651; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15214651 - 02 Nov 2023
Viewed by 870
Abstract
Background: Kashin–Beck disease (KBD) is a distinct osteoarthropathy in China with an unclear pathogenesis. This study aims to explore whether perturbations in the intestine metabolome could be linked to KBD individuals. Methods: An investigation was conducted in KBD endemic villages and [...] Read more.
Background: Kashin–Beck disease (KBD) is a distinct osteoarthropathy in China with an unclear pathogenesis. This study aims to explore whether perturbations in the intestine metabolome could be linked to KBD individuals. Methods: An investigation was conducted in KBD endemic villages and fecal samples were collected. After applying inclusion and exclusion criteria, a total of 75 subjects were enrolled for this study, including 46 KBD (including 19 Grade I KBD and 27 Grade II KBD) and 29 controls. Untargeted metabolomics analysis was performed on the platform of UHPLC-MS. PLS-DA and OPLS-DA were conducted to compare the groups and identify the differential metabolites (DMs). Pathway analysis was conducted on MPaLA platform to explore the functional implication of the DMs. Results: Metabolomics analysis showed that compared with the control group, KBD individuals have a total of 584 differential metabolites with dysregulated levels such as adrenic acid (log2FC = −1.87, VIP = 4.84, p = 7.63 × 10−7), hydrogen phosphate (log2FC = −2.57, VIP = 1.27, p = 1.02 × 10−3), taurochenodeoxycholic acid (VIP = 1.16, log2FC = −3.24, p = 0.03), prostaglandin E3 (VIP = 1.17, log2FC = 2.67, p = 5.61 × 10−4), etc. Pathway analysis revealed several significantly perturbed pathways associated with KBD such as selenium micronutrient network (Q value = 3.11 × 10−3, Wikipathways), metabolism of lipids (Q value = 8.43 × 10−4, Reactome), free fatty acid receptors (Q value = 3.99 × 10−3, Reactome), and recycling of bile acids and salts (Q value = 2.98 × 10−3, Reactome). Subgroup comparisons found a total of 267 differential metabolites were shared by KBD vs. control, KBD II vs. control, and KBD I vs. control, while little difference was found between KBD II and KBD I (only one differential metabolite detected). Conclusions: KBD individuals showed distinct metabolic features characterized by perturbations in lipid metabolism and selenium-related bioprocesses. Our findings suggest that the loss of nutrients metabolism balance in intestine was involved in KBD pathogenesis. Linking the nutrients metabolism (especially selenium and lipid) to KBD cartilage damage should be a future direction of KBD study. Full article
(This article belongs to the Special Issue Nutritional Supplements for Bone Health)
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13 pages, 2875 KiB  
Article
Anti-Osteoporotic Potential of Water Extract of Anethum graveolens L. Seeds
by Seon-A Jang, Sung-Ju Lee, Youn-Hwan Hwang and Hyunil Ha
Nutrients 2023, 15(19), 4302; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15194302 - 09 Oct 2023
Viewed by 964
Abstract
Anethum graveolens L., known as European dill, is a versatile herb widely used in both traditional medicine and culinary practices. Despite its long-standing history, the potential impact of the water extract of A. graveolens seeds (WEAG) on bone health remains unexplored. In this [...] Read more.
Anethum graveolens L., known as European dill, is a versatile herb widely used in both traditional medicine and culinary practices. Despite its long-standing history, the potential impact of the water extract of A. graveolens seeds (WEAG) on bone health remains unexplored. In this study, we investigated the influence of WEAG on osteoclast differentiation and assessed its potential as an anti-osteoporotic agent. WEAG hindered osteoclast differentiation through the suppression of receptor activator of nuclear factor-κB ligand (RANKL) expression in osteoclast-supporting cells and by directly targeting osteoclast precursor cells. WEAG significantly reduced the expression of key osteoclastogenic transcription factors, namely c-Fos and NFATc1, typically induced by RANKL in osteoclast precursors. This reduction was attributed to the suppression of both MAPKs and NF-κB pathways in response to RANKL. In vivo experiments further revealed that WEAG administration effectively reduces trabecular bone loss and weight gain triggered by ovariectomy, mimicking postmenopausal osteoporosis. Furthermore, our comprehensive phytochemical analysis of WEAG identified a range of phytochemical constituents, associated with bone health and weight regulation. Notably, we discovered a specific compound, isorhamnetin-3-O-glucuronide, within WEAG that exhibits anti-osteoclastogenic potential. Overall, this research elucidated the beneficial effects and mechanistic basis of WEAG on osteoclast differentiation and bone loss, indicating its potential as a viable alternative to address bone loss in conditions like postmenopause. Full article
(This article belongs to the Special Issue Nutritional Supplements for Bone Health)
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