Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.0
5.9
Journals
Nutrients
Special Issues
Trace Elements and Bone Health
share announcement

Trace Elements and Bone Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 6311

Special Issue Editors

Dr. Jing Han

E-Mail Website
Guest Editor
Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
Interests: trace elements; articular cartilage; bone; tissue engineering
Dr. Fangfang Yu

E-Mail Website
Guest Editor
Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou 450001, China
Interests: trace elements; diets; articular cartilage; bone

Special Issue Information

Dear Colleagues,

Many nutrition factors are associated with bone health. In particular, trace elements (e.g., zinc, copper, fluorine, manganese, iron, and selenium) can directly participate in bone metabolism and development processes by affecting hormone and enzyme activities. Deficient/excessive amounts of these trace elements slow down the increase in bone mass in childhood and adolescence, and accelerate bone loss after menopause or in old age, which results in rickets, skeletal fluorosis, Kashin–Beck disease, and so on. Therefore, the effects of trace elements on bone health should be focused on worldwide.

Our ambition is for this Special Issue to provide new insights towards the understanding of the roles of trace elements and bone health. We encourage authors to submit their original research focused on this attractive topic. Bioinformatics analyses, clinical trials, cell as well as animal experiments, and systematic reviews describing the association of trace elements with bone health would very well fit as the initiating papers of this Special Issue. Any other suggestions from experts in the field are more than welcome.

Dr. Jing Han
Dr. Fangfang Yu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • trace elements
  • diets
  • articular cartilage
  • bone
  • tissue engineering

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Other

12 pages, 745 KiB  
Article
The Association between Serum Copper and Bone Mineral Density among Adolescents Aged 12 to 19 in the United States
by Haobiao Liu, Miaoye Bao, Mian Liu, Feidan Deng, Xinyue Wen, Ping Wan, Xue Lin, Guoqiang Dong, Zhaoyang Li and Jing Han
Nutrients 2024, 16(3), 453; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16030453 - 04 Feb 2024
Viewed by 1012
Abstract
Bone mineral density (BMD) is a key parameter widely used in the assessment of bone health. Although many investigations have explored the relationship between trace elements and BMD, there are fewer studies focused on serum copper and BMD, especially for adolescents. Using data [...] Read more.
Bone mineral density (BMD) is a key parameter widely used in the assessment of bone health. Although many investigations have explored the relationship between trace elements and BMD, there are fewer studies focused on serum copper and BMD, especially for adolescents. Using data extracted from the National Health and Nutrition Examination Survey, we applied a multiple-linear regression and smooth curve fitting to assess the relationship between serum copper and BMD. A total of 910 participants were finally included in this study. After adjusting for relevant covariates, serum copper was negatively associated with lumbar spine BMD (β = −0.057, 95% CI: −0.109 to −0.005), trunk bone BMD (β = −0.068, 95% CI: −0.110 to −0.026), pelvis BMD (β = −0.085, 95% CI: −0.145 to −0.024), subtotal BMD (β = −0.072, 95% CI: −0.111 to −0.033), and total BMD (β = −0.051, 95% CI: −0.087 to −0.016) (p < 0.05). In quartile analysis, the highest level of serum copper was associated with decreased BMD when compared with those at the lowest quartile (p < 0.05). The stratified analysis revealed a significant interaction between age and the effects of serum copper on trunk bone BMD (p = 0.022) and pelvis BMD (p = 0.018). Meanwhile, the higher level of serum copper was negatively associated with BMD in males, and gender modified the relationship (p < 0.001). Future longitudinal studies will be necessary for a more definitive interpretation of our results. Full article
(This article belongs to the Special Issue Trace Elements and Bone Health)
►▼ Show Figures

Figure 1

15 pages, 7915 KiB  
Article
Network Pharmacology and Molecular Modeling Techniques in Unraveling the Underlying Mechanism of Citri Reticulatae Pericarpium aganist Type 2 Diabetic Osteoporosis
by Jiangtao Li, Ying Wang, Amin Ullah, Ruiyang Zhang, Yuge Sun, Jinjie Li and Guangning Kou
Nutrients 2024, 16(2), 220; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16020220 - 10 Jan 2024
Viewed by 1206
Abstract
Type 2 diabetic osteoporosis (T2DOP) is a common complication in diabetic patients that seriously affects their health and quality of life. The pathogenesis of T2DOP is complex, and there are no targeted governance means in modern medicine. Citri Reticulatae Pericarpium (CRP) is a [...] Read more.
Type 2 diabetic osteoporosis (T2DOP) is a common complication in diabetic patients that seriously affects their health and quality of life. The pathogenesis of T2DOP is complex, and there are no targeted governance means in modern medicine. Citri Reticulatae Pericarpium (CRP) is a traditional Chinese medicine that has a long history and has been used in the treatment of osteoporosis diseases. However, the molecular mechanism for the CRP treatment of T2DOP is not clear. Therefore, this study aimed to explore the underlying mechanisms of CRP for the treatment of T2DOP by using network pharmacology and molecular modeling techniques. By retrieving multiple databases, we obtained 5 bioactive compounds and 63 common targets of bioactive compounds with T2DOP, and identified AKT 1, TP 53, JUN, BCL 2, MAPK 1, NFKB 1, and ESR 1 as the core targets of their PPI network. Enrichment analysis revealed that these targets were mainly enriched in the estrogen signaling pathway, TNF signaling pathway, and AGE-RAGE signaling pathway in diabetics, which were mainly related to oxidative stress and hormonal regulation. Molecular docking and molecular dynamics simulations have shown the excellent binding effect of the bioactive compounds of CRP and the core targets. These findings reveal that CRP may ameliorate T2DOP through multiple multicomponent and multitarget pathways. Full article
(This article belongs to the Special Issue Trace Elements and Bone Health)
►▼ Show Figures

Figure 1

14 pages, 2442 KiB  
Article
Causal Effect of Selenium Levels on Osteoporosis: A Mendelian Randomization Study
by Jinjie Li, Hong Li, Amin Ullah, Shuyuan Yao, Quanjun Lyu and Guangning Kou
Nutrients 2023, 15(24), 5065; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15245065 - 11 Dec 2023
Viewed by 1677
Abstract
Prior research has demonstrated equivocal associations between selenium (Se) concentrations and osteoporosis (OP), yielding inconclusive findings. The purpose of the current study was to examine the potential correlation between Se levels and the risk of OP by using the Mendelian randomization (MR) study [...] Read more.
Prior research has demonstrated equivocal associations between selenium (Se) concentrations and osteoporosis (OP), yielding inconclusive findings. The purpose of the current study was to examine the potential correlation between Se levels and the risk of OP by using the Mendelian randomization (MR) study design. The genetic variants related to Se levels were obtained from a meta-analysis of a Genome-Wide Association Study (GWAS) conducted on toenail Se levels (n = 4162) and blood Se levels (n = 5477). The data summary for OP and bone mineral density (BMD) was obtained by utilizing the GWAS database. To examine the association between Se levels and BMD and OP, we employed three statistical methods: inverse variance weighted, weighted median, and MR-Egger. The reliability of the analysis was verified by sensitivity testing. All three methods of MR analysis revealed that Se levels had no effect on OP risk. In addition, the sensitivity analysis revealed no heterogeneity or pleiotropy, and the significance of the overall effect remained unaffected by single-nucleotide polymorphisms (SNPs), as determined by the leave-one-out analysis, indicating that our findings are relatively reliable. The results of our study indicate that there is no causal association between Se levels and the risk of OP. However, additional investigation is necessary to ascertain whether there is a potential association between these variables. Full article
(This article belongs to the Special Issue Trace Elements and Bone Health)
►▼ Show Figures

Figure 1

Other

Jump to: Research

11 pages, 806 KiB  
Systematic Review
Impact of Vitamin D on Osseointegration in Dental Implants: A Systematic Review of Human Studies
by Berivan Laura Rebeca Buzatu, Roxana Buzatu and Magda Mihaela Luca
Nutrients 2024, 16(2), 209; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16020209 - 09 Jan 2024
Viewed by 1821
Abstract
This systematic review evaluates the impact of Vitamin D levels on dental implant osseointegration, hypothesizing that optimal Vitamin D enhances success rates, and aims to synthesize data on its relationship with clinical outcomes in implantology. A comprehensive search across PubMed, Cochrane Library, and [...] Read more.
This systematic review evaluates the impact of Vitamin D levels on dental implant osseointegration, hypothesizing that optimal Vitamin D enhances success rates, and aims to synthesize data on its relationship with clinical outcomes in implantology. A comprehensive search across PubMed, Cochrane Library, and Web of Science databases included seven peer-reviewed articles meeting the criteria for the review. These studies, conducted between 2008 and 2021, included human subjects and explicitly correlated serum Vitamin D levels with dental implant outcomes, following PRISMA guidelines. The selected studies involved 1462 participants and examined 4450 dental implants. Key findings included a varied implant loss rate ranging from 3.9% to 11.4% across the studies. One study reported a 9.8% implant loss rate, yet found no significant association between Vitamin D receptor polymorphism and implant success. Another study indicated successful implantation following Vitamin D3 supplementation, even in severe deficiency cases. The highest implant loss rate (11.1%) was observed in severely Vitamin D-deficient patients, particularly when compounded by risk factors such as smoking and periodontal disease. Additionally, one study noted significantly improved bone density following post-surgical Vitamin D supplementation for up to 12 weeks. The review supports a link between sufficient Vitamin D levels and successful dental implant osseointegration, suggesting Vitamin D deficiency as a potential risk factor for increased failure and advocating for Vitamin D evaluations in pre-surgical planning to potentially enhance implantology outcomes. Full article
(This article belongs to the Special Issue Trace Elements and Bone Health)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop