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Nutrients
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Food Allergy and Immunity
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Food Allergy and Immunity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: closed (20 December 2023) | Viewed by 3192

Special Issue Editors

Dr. Francisca Palomares

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Guest Editor
Department of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville. Av. Sanchez Pizjuan s/n, 41009 Seville, Spain
Interests: biochemistry; molecular and cellular biology; immunology; nutraceuticals; dendritic cells; type 2 innate lymphoid cells; food allergy; immunotherapy; nanostructures
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Soledad Lopez-Enriquez

E-Mail Website
Guest Editor
Department of Medical Biochemistry, Molecular Biology, Immunology School of Medicine, Universidad de Sevilla, Av. Sanchez Pizjuan s/n, 41009 Seville, Spain
Interests: food; nutrients; immunology; innate and adaptative response; immunometabolism; signaling pathways; flow cytometry; cell culture; allergy; allergic rhinitis; chronic rhinosinusitis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nutrition is a fundamental issue in food allergy. It is becoming an increasingly serious problem around the world, affecting almost 10% of children. When this pathology develops in children, the nutritional contribution they receive is the least adequate, since they are advised to avoid the intake of foods that induce food allergic reaction.

This Special Issue will provide information on the tools that are available for the diagnosis and treatment of food allergies. This Special Issue will include manuscripts that focus on nutrition, nutritional treatment (use of nutraceuticals), and new therapeutic approaches in food allergies. The presented materials are the result of the international scientific cooperation of experts that specialize in these issues. The content may be useful for clinical results to help in the diagnosis and treatment of food allergies.

Dr. Francisca Palomares
Prof. Dr. Soledad Lopez-Enriquez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergy
  • nutraceuticals
  • diagnostic and treatment
  • immunity

Published Papers (2 papers)

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Research

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13 pages, 1315 KiB  
Article
The Combination of Binding Avidity of Ovomucoid-Specific IgE Antibody and Specific IgG4 Antibody Can Predict Positive Outcomes of Oral Food Challenges during Stepwise Slow Oral Immunotherapy in Children with Hen’s Egg Allergy
by Shoichiro Taniuchi, Rika Sakai, Takahiro Nishida, Meguru Goma, Masatoshi Mitomori, Aya Imaide, Masahiro Enomoto, Masamitsu Nishino, Yo Okizuka and Hiroshi Kido
Nutrients 2023, 15(12), 2770; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15122770 - 16 Jun 2023
Cited by 1 | Viewed by 1113
Abstract
To increase the prediction accuracy of positive oral food challenge (OFC) outcomes during stepwise slow oral immunotherapy (SS-OIT) in children with a hen’s egg (HE) allergy, we evaluated the predictive value of the combination of antigen-specific IgE (sIgE) with antigen binding avidity and [...] Read more.
To increase the prediction accuracy of positive oral food challenge (OFC) outcomes during stepwise slow oral immunotherapy (SS-OIT) in children with a hen’s egg (HE) allergy, we evaluated the predictive value of the combination of antigen-specific IgE (sIgE) with antigen binding avidity and sIgG4 values. Sixty-three children with HE allergy undergoing SS-OIT were subjected to repeated OFCs with HE. We measured the ovomucoid (OVM)-sIgE by ImmunoCAP or densely carboxylated protein (DCP) microarray, sIgG4 by DCP microarray, and the binding avidity of OVM-sIgE defined as the level of 1/IC50 (nM) measured by competitive binding inhibition assays. The OFC was positive in 37 (59%) patients undergoing SS-OIT. Significant differences in DCP-OVM-sIgE, CAP-OVM-sIgE, I/IC50, DCP-OVM-sIgG4, the multiplication products of DCP-OVM-sIgE, and the binding avidity of DCP-OVM-sIgE (DCP-OVM-sIgE/IC50) and DCP-OVM-sIgE/sIgG4 were compared between the negative and positive groups (p < 0.01). Among them, the variable with the greatest area under the receiver operating characteristic curve was DCP-OVM-sIgE/IC50 (0.84), followed by DCP-OVM-sIgE/sIgG4 (0.81). DCP-OVM-sIgE/IC50 and DCP-OVM-sIgE/sIgG4 are potentially useful markers for the prediction of positive OFCs during HE-SS-OIT and may allow proper evaluation of the current allergic status in the healing process during HE-SS-OIT. Full article
(This article belongs to the Special Issue Food Allergy and Immunity)
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Review

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19 pages, 1753 KiB  
Review
Update on In Vitro Diagnostic Tools and Treatments for Food Allergies
by Mariano Brasal-Prieto, Laura Fernández-Prades, Hala Dakhaoui, Francisco Sobrino, Soledad López-Enríquez and Francisca Palomares
Nutrients 2023, 15(17), 3744; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15173744 - 26 Aug 2023
Cited by 2 | Viewed by 1789
Abstract
Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger a wide range of symptoms from mild to life-threatening. This adverse reaction is caused by different immunological mechanisms, such as IgE-mediated, non-IgE-mediated and mixed IgE-mediated reactions. Its epidemiology [...] Read more.
Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger a wide range of symptoms from mild to life-threatening. This adverse reaction is caused by different immunological mechanisms, such as IgE-mediated, non-IgE-mediated and mixed IgE-mediated reactions. Its epidemiology has had a significant increase in the last decade, more so in developed countries. It is estimated that approximately 2 to 10% of the world’s population has FA and this number appears to be increasing and also affecting more children. The diagnosis can be complex and requires the combination of different tests to establish an accurate diagnosis. However, the treatment of FA is based on avoiding the intake of the specific allergenic food, thus being very difficult at times and also controlling the symptoms in case of accidental exposure. Currently, there are other immunomodulatory treatments such as specific allergen immunotherapy or more innovative treatments that can induce a tolerance response. It is important to mention that research in this field is ongoing and clinical trials are underway to assess the safety and efficacy of these different immunotherapy approaches, new treatment pathways are being used to target and promote the tolerance response. In this review, we describe the new in vitro diagnostic tools and therapeutic treatments to show the latest advances in FA management. We conclude that although significant advances have been made to improve therapies and diagnostic tools for FA, there is an urgent need to standardize both so that, in their totality, they help to improve the management of FA. Full article
(This article belongs to the Special Issue Food Allergy and Immunity)
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