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Nutrients
Special Issues
Dietary Antioxidants and Oxidative Stress in Brain Health
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Dietary Antioxidants and Oxidative Stress in Brain Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 3168

Special Issue Editors

Dr. Pradoldej Sompol

E-Mail Website
Guest Editor
Sanders-Brown Center on Aging, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY, USA
Interests: antioxidants; natural antioxidants; aging; pathophysiology of Alzheimer’s disease and related dementias; Alzheimer’s disease; vascular dementia; astrocyte
Prof. Dr. Anna Gramza-Michałowska

E-Mail Website
Guest Editor
Department of Gastronomy Sciences and Functional Foods, Faculty of Food Science and Nutrition, Poznań University of Life Sciences, Poznań, Poland
Interests: functional food; food product development; food chemistry; bioactive compounds; antioxidant activity; nutraceuticals; natural compounds; polyphenols; flavonoids; nutritional value; food and health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Antioxidants are substances that could offset oxidative stress, an imbalance between the production and neutralization of reactive oxygen species (ROS). Oxidative stress is one of the major factors that regulates brain health. Dysregulation of the counterbalance mechanisms drives the pathophysiology of brain diseases. Exposure to factors that increase oxidative stress such as foods, drugs, alcohol, chemicals, smoking, pollution, radiation treatment, pathogens and lifestyle-related stress conditions can increase the risk of brain damage and brain dysfunction. Antioxidant machinery, both endogenous and exogenous, is essential for blocking oxidative stress processes. Supplementation of exogenous dietary antioxidants could slow down aging, age-related degeneration, and inflammatory mechanisms, which could benefit brain health. This Special Issue welcomes articles that provide insights into the pathways and ways dietary antioxidants can enhance our complex brain systems and prevent brain disease.

Dr. Pradoldej Sompol
Prof. Dr. Anna Gramza-Michałowska
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary antioxidant
  • supplement
  • enzyme
  • oxidative stress
  • mitochondria
  • astrocyte
  • microglia
  • neuron
  • cerebrovascular
  • aging

Published Papers (1 paper)

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Review

31 pages, 1654 KiB  
Review
Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents
by Himadri Sharma, Niti Sharma and Seong Soo A. An
Nutrients 2024, 16(1), 102; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16010102 - 27 Dec 2023
Viewed by 2816
Abstract
Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, [...] Read more.
Cordyceps, also known as “zombie fungus”, is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a “zombie”. These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol. Cordyceps has been used in traditional medicine due to its immense health benefits, as it boosts stamina, appetite, immunity, longevity, libido, memory, and sleep. Neuronal loss is the typical feature of neurodegenerative diseases (NDs) (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS)) and neurotrauma. Both these conditions share common pathophysiological features, like oxidative stress, neuroinflammation, and glutamatergic excitotoxicity. Cordyceps bioactives (adenosine, N6-(2-hydroxyethyl)-adenosine, ergosta-7, 9 (11), 22-trien-3β-ol, active peptides, and polysaccharides) exert potential antioxidant, anti-inflammatory, and anti-apoptotic activities and display beneficial effects in the management and/or treatment of neurodegenerative disorders in vitro and in vivo. Although a considerable list of compounds is available from Cordyceps, only a few have been evaluated for their neuroprotective potential and still lack information for clinical trials. In this review, the neuroprotective mechanisms and safety profile of Cordyceps extracts/bioactives have been discussed, which might be helpful in the identification of novel potential therapeutic entities in the future. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Oxidative Stress in Brain Health)
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