Dear Colleagues,

Cancer is the leading cause of death in Japan. The government has taken various measures to extend healthy life expectancy, but the incidence of cancer is increasing year by year, which is not a common trend in most developed countries but rather unique to Japan. It is speculated that one of the reasons for this is the increase in the obese population due to the westernization of diet in Japanese lifestyle. Obesity is located upstream of metabolic syndrome and has been reported to be one of the risk factors for causing NAFLD/NASH and developing liver cancer. It has also been reported that even if surgery for cancer of various organs is successful, CTCs (circulating tumor cells) are likely to form metastatic lesions due to the effects of inflammatory reactions and cytokines, depending on the nutritional status after surgery. On the other hand, in Japan, not only cancer but also COPD improvement effect and nutrition therapy problems are very big issues to be solved. Furthermore, in the recent global corona pandemic, the problems of deterioration of oral flora (environment) and intestinal flora (environment) and carcinogenic risk have also attracted attention, and nutrition (including human fecal microbiota transplantation, FMT) is also attracting attention, so its relationship with cancer cannot be ignored. At the same time, nutrition and rejuvenation (anti-aging), hydrogen gas inhalation, and mitochondrial metabolic activity are also very important issues. In this growing and unprecedented corona pandemic, aging is also closely associated with aggravation, and the ultimate deterioration can lead to corona death. Therefore, everyone wants to control aging, avoid the risk of cancer as much as possible, and strengthen immunity.

These topics taken together, the purpose of this Special Issue is to identify how to achieve aging control by actively utilizing nutrition and various nutrition-related means to reduce the risk of cancer. We invite papers (reviews/clinical trials/experimental research/clinical reports, etc.) from experts in various fields that focus on countermeasures that can be taken.

Prof. Dr. Yoshitaka Fukuzawa
Dr. Daiki Jimbo
Guest Editors

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• Cancer death
• Obesity
• Extended healthy life expectancy
• NAFLD/NASH
• COPD
• Oral/intestinal flora (environment)
• Mitochondria
• Hydrogen
• Rejuvenation (anti-aging)
• Corona epidemic