The Role of Dietary Bioactive Compounds on Immune and Inflammation-Related Diseases

Dear Colleagues,

Much interest has been focused on the anti-inflammatory and anti-oxidant activities of plant-derived bioactive molecules. These factors show their synergistic activity and have been described to complement therapeutic drugs, lowering very often the side effects, increasing in this way the compliance of patients. Cytokines and chemokines released by innate immunity cells play a central role in the development and progression of several very widespread diseases, including cardiovascular and central nervous system diseases. The immune system responds to exogenous and endogenous stresses, and particular importance is provided to the interaction with microbiota, which has the ability to polarize the cells of the immune system towards a pro- or anti-inflammatory phenotype. The aim of this Special Issue is to collect the most updated information on new experimental results and literature reviews on the properties displayed by bioactive molecules capable of influencing the course of many important diseases, targeting different parts of our body.

Ageing, the main condition behind a broad spectrum of chronic disorders that are factors inducing AD, PD, depression, and a lower quality of life in the older age and elderly groups. Personalized medicine, pre- and probiotics, and modern technologies are designed to counteract the negative effects of the ageing condition through focus upon anti-inflammatory and autophagy to redress the homeostatic balance at cellular and tissue sites in cell culture studies. Probiotic preparations, such as yeasts or bacteria, may mimic the effects of the tenet, 'exercising more, eating less', whereas other anti-ageing molecules from molecular gerontologists and epigeneticists may contribute to improving 'health span' and ‘longevity’ among the aged people.

This Special Issue of Nutrients entitled “The Role of Dietary Bioactive Compounds on Immune and Inflammation-Related Diseases” welcomes original research articles and literature reviews on this important topic.

Dr. Rita Businaro
Guest Editor

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• bioactive compounds
• nutraceuticals
• microbiota
• innate immunity
• adaptive immunity
• cytokines
• chemokines
• chronic degenerative diseases
• ageing
• inflammageing