Special Issue "Nutrition and the Risk of Cardiovascular Diseases"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 30 January 2022.

Special Issue Editor

Prof. Dr. Karani S. Vimaleswaran
E-Mail Website
Guest Editor
Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6DZ, UK
Interests: nutrient–gene interactions; nutrigenetics; nutrigenomics; obesity; diabetes; cardiovascular disease; gut microbiome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) are one of the most important causes of death globally, taking an estimated 17.9 million lives each year. The development of CVD is associated with unhealthy dietary lifestyle together with a lack of exercise, overweight and obesity, stress, alcohol consumption, or a smoking habit. Studies have shown the effectiveness of healthy dietary patterns and lifestyles for the prevention of CVD. Furthermore, the rising incidence of CVD over the last 25 years has become a public health priority, especially the prevention of CVD through dietary interventions. Furthermore, biomarkers and genetic data have also helped enrich the fields of clinical, genetic, and biological research pertaining to CVD. Given that CVD is a complex multifactorial disease, there are unique opportunities to investigate novel biomarkers, gene–environment interactions, epigenetic, metabolomic, and gut microbiome markers in relation to the risk of CVD. Increasing the knowledge in these areas of research will be helpful for the development of evidence-based nutrition guidelines for the prevention and management of CVD.

This Special Issue, “Nutrition and the Risk of Cardiovascular Diseases”, welcomes manuscripts related to human and animal studies focused on the roles of dietary and related lifestyle factors, genetic, epigenetic, nutrigenetic, nutrigenomic, metabolomic and microbiome markers in CVD, as well as in vitro studies aimed at elucidating the potential molecular mechanisms of the role of macro- and micro-nutrients in CVDs. Experimental papers, review articles, and commentaries are all welcome.

Prof. Dr. Karani S. Vimaleswaran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrition
  • dietary pattern
  • cardiovascular disease
  • nutrigenetics
  • nutrigenomics
  • metabolomics
  • epigenetics
  • microbiome

Published Papers (2 papers)

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Research

Article
Impact of Controlling a Nutritional Status Score on Wound Healing in Patients with Chronic Limb-Threatening Ischemia after Endovascular Treatment
Nutrients 2021, 13(11), 3710; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13113710 - 22 Oct 2021
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Abstract
Background: Chronic limb-threatening ischemia (CLTI) is the most advanced stage of peripheral artery disease. Therefore, a multidisciplinary approach is necessary to avoid major amputation in CLTI patients. Malnutrition worsens the condition of CLTI patients, and therefore, it may be important to evaluate the [...] Read more.
Background: Chronic limb-threatening ischemia (CLTI) is the most advanced stage of peripheral artery disease. Therefore, a multidisciplinary approach is necessary to avoid major amputation in CLTI patients. Malnutrition worsens the condition of CLTI patients, and therefore, it may be important to evaluate the nutritional status in patients with CLTI. This study was designed to evaluate the baseline patient characteristics and the influence of the controlling nutritional status (CONUT) score on the clinical results. Method and Results: A retrospective, single-center, non-randomized study was conducted to evaluate the associations of death, major amputation, and wound healing rate at 12 months with the CONUT score on admission. Consecutive CLTI patients (mean age 73.2 ± 10.4 years; 84 males) who underwent endovascular therapy (EVT) for infra-popliteal lesions at Fukuoka University Hospital from January 2014 to May 2019 were enrolled and divided into two groups (higher and lower CONUT score groups). The higher CONUT group showed a higher percentage of dialysis (66.7% vs. 33.9%, p < 0.001) and a higher clinical frailty scale (5.9 ± 1.4 vs. 4.9 ± 1.9, p = 0.005) than the lower CONUT group. Rates of amputation-free survival were 89.5% and 69.8% in the lower and higher CONUT groups, respectively. In addition, rates of wound healing at 12 months were 98.0% and 78.3% in the lower and higher CONUT groups, respectively. Multivariate regression analysis demonstrated that a higher CONUT score was an independent predictor for delayed wound healing (OR: 11.2; 95% CI: 1.29–97.5; p = 0.028). Conclusion: An assessment of the nutritional status using the CONUT score could be useful for predicting wound healing, and earlier nutritional intervention may improve the outcome of CLTI patients. Early examination and treatment, along with raising awareness of the issue, may be important for improving the prognosis. Full article
(This article belongs to the Special Issue Nutrition and the Risk of Cardiovascular Diseases)
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Article
Lower Dietary Intake of Plant Protein Is Associated with Genetic Risk of Diabetes-Related Traits in Urban Asian Indian Adults
Nutrients 2021, 13(9), 3064; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093064 - 31 Aug 2021
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Abstract
The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine the impact of dietary and genetic factors on metabolic traits in 1062 Asian Indians. Dietary assessment was performed [...] Read more.
The increasing prevalence of type 2 diabetes among South Asians is caused by a complex interplay between environmental and genetic factors. We aimed to examine the impact of dietary and genetic factors on metabolic traits in 1062 Asian Indians. Dietary assessment was performed using a validated semi-quantitative food frequency questionnaire. Seven single nucleotide polymorphisms (SNPs) from the Transcription factor 7-like 2 and fat mass and obesity-associated genes were used to construct two metabolic genetic risk scores (GRS): 7-SNP and 3-SNP GRSs. Both 7-SNP GRS and 3-SNP GRS were associated with a higher risk of T2D (p = 0.0000134 and 0.008, respectively). The 3-SNP GRS was associated with higher waist circumference (p = 0.010), fasting plasma glucose (FPG) (p = 0.002) and glycated haemoglobin (HbA1c) (p = 0.000066). There were significant interactions between 3-SNP GRS and protein intake (% of total energy intake) on FPG (Pinteraction = 0.011) and HbA1c (Pinteraction = 0.007), where among individuals with lower plant protein intake (<39 g/day) and those with >1 risk allele had higher FPG (p = 0.001) and HbA1c (p = 0.00006) than individuals with ≤1 risk allele. Our findings suggest that lower plant protein intake may be a contributor to the increased ethnic susceptibility to diabetes described in Asian Indians. Randomised clinical trials with increased plant protein in the diets of this population are needed to see whether the reduction of diabetes risk occurs in individuals with prediabetes. Full article
(This article belongs to the Special Issue Nutrition and the Risk of Cardiovascular Diseases)
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