Special Issue "Prevention Strategies and Treatment Interventions of Diabetes and Its Complications and Metabolic Disorders"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (20 October 2021).

Special Issue Editors

Dr. Sergio Martínez-Hervás
E-Mail Website
Guest Editor
Department of Medicine, University of Valencia, Av. Blasco Ibáñez 15, 46010 Valencia, Spain
Interests: atherosclerosis; inflammation; dyslipidemia; insulin resistance; diabetes
Special Issues, Collections and Topics in MDPI journals
Dr. Herminia González-Navarro
E-Mail Website
Guest Editor
Health Research Institute Clinic Hospital of Valencia – INCLIVA, Menéndez Pelayo 4, 46010 Valencia, Spain
Interests: atherosclerosis; inflammation; dyslipidemia; insulin resistance; diabetes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Prevalence of diabetes and metabolic disorders such as dyslipidemia or obesity has increased in the last years which supposes a large economic and social burden. Diabetes is a major public health problem, being one of the major contributors to death and ill health globally, representing a major cause of blindness, kidney failure and lower limb amputation. Diabetes is also one of the most important contributors to the development of cardiovascular disease. Furthermore, in the last years several data suggest that diabetes is accompanied with frailty as well as disability among the older adults, observing a significant relationship between diabetes and frailty, mortality and hospitalization.

Considering the clinical significance of diabetes and its complications, prevention strategies are crucial to reduce the incidence of diabetes. Once diabetes develops, a variety of therapeutic steps may be clinically indicated to improve disease management and to prevent, or at least to delay, chronic complications. Furthermore, it is also important to evaluate risk factors implicated in the development of diabetes and its complications in order to find new therapeutic interventions. Additionally, it is required to meet the increasing demand of managing older diabetic patients with the population aging.

On the other hand, obesity is also a high prevalent disorder. Its prevalence has increased exponentially. Obesity is related to type 2 diabetes, stroke, heart disease, functional disability and certain types of cancer that are some of the leading causes of preventable, premature death. Furthermore, obesity has been associated with different metabolic disturbances. In this sense, prevention and treatment of obesity are also crucial to reduce the appearance of complications and mortality.

This Special Issue welcomes the submission of manuscripts describing original research or systematic or narrative reviews of the scientific literature. The proposed manuscripts should cover the risk factors for developing obesity, diabetes and its complications, and interventions to delay the incidence of both entities or to delay the development of chronic compliactions. Also, papers regarding other metabolic diseases such as dyslipidemia are welcome.

Topics for this special issue may include but are not limited to:

- Nutrition and therapy in the management and prevention of diabetes and/or obesity

- Nutrition and therapy in the management and prevention of dyslipidemia

- Assessing non-traditional risk factors associated with frailty in subjects with diabetes

- Strategies to prevent and to treat diabetes and its chronic complications

Dr. Sergio Martínez-Hervás
Dr. Herminia González-Navarro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Diabetes
  • Obesity
  • Dyslipidemia
  • Prevention
  • Frailty
  • Incidence

Published Papers (3 papers)

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Research

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Article
Frailty Is Associated with Oxidative Stress in Older Patients with Type 2 Diabetes
Nutrients 2021, 13(11), 3983; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13113983 - 09 Nov 2021
Viewed by 635
Abstract
Aging has increased the prevalence of frailty, and type 2 diabetes (T2D) has also increased in prevalence. Diabetes and oxidative stress (OS) have been shown to be related to frailty. However, the exact mechanism by which it occurs is not fully known. Our [...] Read more.
Aging has increased the prevalence of frailty, and type 2 diabetes (T2D) has also increased in prevalence. Diabetes and oxidative stress (OS) have been shown to be related to frailty. However, the exact mechanism by which it occurs is not fully known. Our aim was to analyze body composition in community-dwelling older diabetic people treated in our center and to evaluate the possible relation between OS, frailty, and body composition. We included 100 adults older than 65 years with T2D. We found that 15% were frail and 57% were prefrail. The patients included in the nonrobust group showed increased levels of OS. Our study shows that the presence of T2D in the geriatric population is associated with a high prevalence of frailty and high OS levels, conditions that cause greater morbidity and mortality and that highlight the importance of the diagnosis of frailty in this population. Full article
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Review

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Review
Remission of Type 2 Diabetes with Very Low-Calorie Diets—A Narrative Review
Nutrients 2021, 13(6), 2086; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13062086 - 18 Jun 2021
Viewed by 1858
Abstract
Very low-calorie diets (VLCD) are hypocaloric dietary regimens of approximately 400–800 kcal/day that result in 20–30% reductions in body weight, sometimes in just 12–16 weeks. A body of evidence demonstrates that adherence to VLCD in adults with type 2 diabetes (T2D) can result [...] Read more.
Very low-calorie diets (VLCD) are hypocaloric dietary regimens of approximately 400–800 kcal/day that result in 20–30% reductions in body weight, sometimes in just 12–16 weeks. A body of evidence demonstrates that adherence to VLCD in adults with type 2 diabetes (T2D) can result in marked improvements to glycemic control and even full T2D remission, challenging the convention that T2D is a lifelong disease. Although these data are promising, the majority of VLCD studies have focused on weight loss and not T2D remission as a primary endpoint. Moreover, there is a wide range of VLCD protocols and definitions of T2D remission used across these hypocaloric studies. Together the large degree of heterogeneity in VLCD studies, and how T2D remission is defined, leave many gaps in knowledge to efficacy and durability of VLCD approaches for T2D remission. This narrative review examines findings from a body of data from VLCD studies that specifically sought to investigate T2D remission, and discusses the efficacy of VLCD compared to other hypocaloric approaches, and who is likely to benefit from VLCD approaches for T2D remission. Full article

Other

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Systematic Review
Influence of Vitamin D Supplementation on Mental Health in Diabetic Patients: A Systematic Review
Nutrients 2021, 13(11), 3678; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13113678 - 20 Oct 2021
Cited by 2 | Viewed by 560
Abstract
Diabetes is associated with a number of mental health consequences, including enhanced risk of depression and anxiety, as well as decreased quality of life, and vitamin D deficiency is considered to be one of the factors that influence these outcomes in diabetic patients. [...] Read more.
Diabetes is associated with a number of mental health consequences, including enhanced risk of depression and anxiety, as well as decreased quality of life, and vitamin D deficiency is considered to be one of the factors that influence these outcomes in diabetic patients. The aim of the present study was to conduct a systematic review of the literature presenting the data regarding the influence of vitamin D supplementation on mental health in diabetic adults. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration number CRD42020155779). A systematic search of the PubMed and Web of Science databases was performed, and the intervention studies published until September 2021 were included in the review. The human studies were included if an adult sample of diabetic individuals received vitamin D supplementation during the intervention and its effect on any mental health aspect was assessed, but studies presenting the influence of combined supplementation of multiple nutrients were excluded. After removing duplicate records, a total of 8514 publications were screened and assessed independently by two researchers, based on their title, abstract, and full text. Finally, six studies were included in the current systematic review, and the risk of bias was evaluated using the Newcastle–Ottawa Scale (NOS). The included studies analyzed the influence of a specific dose of vitamin D, or different doses of vitamin D, or compared the results of supplementation with a specific dose of vitamin D against the placebo group. The supplementation was performed for at least 12 weeks. The mental health outcomes analyzed in these studies included health-related quality of life, depression, anxiety, stress, and general mental health status of adult diabetic patients. The results of the majority of the studies confirmed the positive influence of vitamin D supplementation on the mental health of diabetic individuals. Those studies that analyzed the influence of vitamin D supplementation on depression and anxiety established the beneficial effect of the vitamin. In some studies, the influence of vitamin D supplementation on the health-related quality of life was not considered unless combined with mindfulness training. However, it must be emphasized that different dosage regimens and intervention periods were followed in the reviewed studies, and only a small number of studies were randomized against placebo, which should be considered as a limitation of the present study. The findings of the conducted systematic review demonstrated the positive influence of vitamin D supplementation on the mental health of diabetic patients, which was proved for anxiety and depression, but in the case of health-related quality of life, the positive effect was observed only when the intervention included mindfulness training. These outcomes suggest that supplementation should be recommended to improve the vitamin D status and the mental health of patients in this group. Full article
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