The Health Benefits of Nutritional Composition in Functional Foods

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 998

Special Issue Editor


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Guest Editor
Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece
Interests: functional foods; metabolic health; clinical nutrition; sport nutrition; substance use disorders; addictive behaviours
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Special Issue Information

Dear Colleagues,

Functional foods are thought to provide health benefits beyond basic nutrition as they are high in bioactive compounds that exert beneficial health effects. They typically contain high amounts of important nutrients, vitamins, minerals, amino acids, healthy fats, fibre, polyphenols, or other nutrients that increase their nutritional value. The increased consumption of a variety of functional foods can protect against nutrient deficiencies and contribute to the prevention or treatment of various diseases, including cardiovascular diseases, obesity, diabetes, neurodegenerative diseases, and cancer. As the interest of consumers of functional foods has grown and non-pharmacological treatments have became more essential, demands for evidence-based information about the nutritional composition and health benefits of functional foods have emerged.

We are pleased to showcase original research, study protocols, short communications, brief reviews, and reviews (including systematic reviews and meta-analyses) on the nutritional composition and health benefits of functional foods in the prevention or treatment of non-communicable diseases.

Dr. Kalliopi Georgakouli
Guest Editor

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Keywords

  • nutraceuticals
  • bioactive compounds
  • antioxidants
  • phytochemicals
  • health
  • prevention

Published Papers (1 paper)

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Research

15 pages, 3408 KiB  
Article
Kaempferol Improves Cardiolipin and ATP in Hepatic Cells: A Cellular Model Perspective in the Context of Metabolic Dysfunction-Associated Steatotic Liver Disease
by Akiko Sakurai, Toshihiro Sakurai, Hsin-Jung Ho, Hitoshi Chiba and Shu-Ping Hui
Nutrients 2024, 16(4), 508; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16040508 - 11 Feb 2024
Viewed by 807
Abstract
Targeting mitochondrial function is a promising approach to prevent metabolic dysfunction-associated steatotic liver disease (MASLD). Cardiolipin (CL) is a unique lipid comprising four fatty acyl chains localized in the mitochondrial inner membrane. CL is a crucial phospholipid in mitochondrial function, and MASLD exhibits [...] Read more.
Targeting mitochondrial function is a promising approach to prevent metabolic dysfunction-associated steatotic liver disease (MASLD). Cardiolipin (CL) is a unique lipid comprising four fatty acyl chains localized in the mitochondrial inner membrane. CL is a crucial phospholipid in mitochondrial function, and MASLD exhibits CL-related anomalies. Kaempferol (KMP), a natural flavonoid, has hepatoprotective and mitochondrial function-improving effects; however, its influence on CL metabolism in fatty liver conditions is unknown. In this study, we investigated the effects of KMP on mitochondrial function, focusing on CL metabolism in a fatty liver cell model (linoleic-acid-loaded C3A cell). KMP promoted mitochondrial respiratory functions such as ATP production, basal respiration, and proton leak. KMP also increased the gene expression levels of CPT1A and PPARGC1A, which are involved in mitochondrial β-oxidation. Comprehensive quantification of CL species and related molecules via liquid chromatography/mass spectrometry showed that KMP increased not only total CL content but also CL72:8, which strongly favors ATP production. Furthermore, KMP improved the monolysocardiolipin (MLCL)/CL ratio, an indicator of mitochondrial function. Our results suggest that KMP promotes energy production in a fatty liver cell model, associated with improvement in mitochondrial CL profile, and can serve as a potential nutrition factor in preventing MASLD. Full article
(This article belongs to the Special Issue The Health Benefits of Nutritional Composition in Functional Foods)
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