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Alcohol Intake and Human Health
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Alcohol Intake and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (25 April 2024) | Viewed by 2797

Special Issue Editors

Dr. Danielle E Levitt

E-Mail Website
Guest Editor
Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX 79409, USA
Interests: alcohol; bioenergetics; skeletal muscle; metabolic health; exercise
Dr. Liz Simon

E-Mail Website
Guest Editor
1. Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
2. Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
Interests: alcohol; metabolism; HIV; skeletal muscle

Special Issue Information

Dear Colleagues,

Alcohol is the most commonly used substance of misuse worldwide. According to the World Health Organization (WHO), alcohol contributes to approximately 3 million deaths annually and over 200 disease states. Adverse impacts of alcohol misuse, alcohol metabolism, or alcohol metabolites have been reported in nearly every organ system, underscoring its potential to influence human health.

In this Special Issue, we aim to highlight articles that provide new insights into the impact of alcohol on human health, or advance our understanding of treatment targets and approaches. We welcome original research and review articles. While studies including human participants or human data are encouraged, studies using preclinical, in vitro, or in silico approaches are also acceptable provided that the link to informing human health is clear.

Dr. Danielle E Levitt
Dr. Liz Simon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alcohol
  • tissue injury
  • mechanisms
  • pathophysiology
  • epidemiology
  • treatment

Published Papers (2 papers)

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Research

15 pages, 1328 KiB  
Article
High Adherence to a Mediterranean Alcohol-Drinking Pattern and Mediterranean Diet Can Mitigate the Harmful Effect of Alcohol on Mortality Risk
by Angelo Campanella, Caterina Bonfiglio, Francesco Cuccaro, Rossella Donghia, Rossella Tatoli and Gianluigi Giannelli
Nutrients 2024, 16(1), 59; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16010059 - 24 Dec 2023
Cited by 1 | Viewed by 1318
Abstract
Background: Alcohol is a psychoactive substance with deleterious effects on human health and mortality. This study aims to investigate the joint associations between the Mediterranean Diet (MedDiet), alcohol- consumption patterns and mortality from the following: all causes, cardiovascular, neoplastic, the digestive system, and [...] Read more.
Background: Alcohol is a psychoactive substance with deleterious effects on human health and mortality. This study aims to investigate the joint associations between the Mediterranean Diet (MedDiet), alcohol- consumption patterns and mortality from the following: all causes, cardiovascular, neoplastic, the digestive system, and other causes. Methods: A sample of 3411 alcohol consumers aged ≥18 years was selected from two prospective cohort studies: the MICOL and NUTRIHEP Study. Cohorts were enrolled in 2005–2006, and followed up until December 2022, capturing data on alcohol consumption, diet, and mortality. Adherence to the MedDiet was measured by the relative Mediterranean score (rMED), and alcohol consumption by the Mediterranean Alcohol-drinking Pattern index (MADP). Statistical analyses included flexible parametric survival models and subdistribution hazard ratios, to consider different causes of death. Results: a significant increase in digestive-system (SHR 2.77, 95% CI 1.16; 63) and cancer mortality risk (SHR 2.25, 95% CI 1.08; 4.70) was observed among individuals with low adherence to the MADP. Low adherence to the Mediterranean pattern of alcohol consumption, combined with low adherence to the MedDiet, was associated with higher overall mortality (HR 2.29, 95% CI 1.04, 5.04), and, in particular, with higher mortality from digestive system diseases (SHR 4.38, 95% CI 1.22, 15.8). Conclusions: This study suggests that deleterious effects of alcohol on mortality vary, depending on alcohol consumption patterns and dietary context. Higher adherence to the MedDiet appears to mitigate the adverse effects of moderate alcohol consumption, particularly for wine drinkers. Full article
(This article belongs to the Special Issue Alcohol Intake and Human Health)
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16 pages, 4741 KiB  
Article
Red Rice Seed Coat Targeting SPHK2 Ameliorated Alcoholic Liver Disease via Restored Intestinal Barrier and Improved Gut Microbiota in Mice
by Yuxu Chen, Zhiye Zhao, Shancheng Guo, Yaxian Li, Haiaolong Yin, Lei Tian, Guiguang Cheng and Ye Li
Nutrients 2023, 15(19), 4176; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15194176 - 27 Sep 2023
Viewed by 1018
Abstract
Alcoholic liver disease (ALD), leading to the most common chronic liver diseases, is increasingly emerging as a global health problem, which is intensifying the need to develop novel treatments. Herein, our work aimed to estimate the therapeutic efficacy of red rice (Oryza [...] Read more.
Alcoholic liver disease (ALD), leading to the most common chronic liver diseases, is increasingly emerging as a global health problem, which is intensifying the need to develop novel treatments. Herein, our work aimed to estimate the therapeutic efficacy of red rice (Oryza sativa L.) seed coat on ALD and further uncover the underlying mechanisms. Red rice seed coat extract (RRA) was obtained with citric acid–ethanol and analyzed via a widely targeted components approach. The potential targets of RRA to ALD were predicted by bioinformatics analysis. Drunken behavior, histopathological examination, liver function, gut microbiota composition and intestinal barrier integrity were used to assess the effects of RRA (RRAH, 600 mg/kg·body weight; RRAL, 200 mg/kg·body weight) on ALD. Oxidative stress, inflammation, apoptosis associated factors and signaling pathways were measured by corresponding kits, Western blot and immunofluorescence staining. In ALD model mice, RRA treatment increased sphingosine kinase 2 (SPHK2) and sphingosine-1-phosphate (S1P) levels, improved gut microbiota composition, restored intestinal barrier, decreased lipopolysaccharide (LPS) levels in plasma and the liver, cut down Toll-like receptor 4 (TLR4)/Nuclear factor kappa B (NF-κB) pathways, alleviated liver pathological injury and oxidative stress, attenuated inflammation and apoptosis and enhanced liver function. To sum up, RRA targeting SPHK2 can ameliorate ALD by repairing intestinal barrier damage and reducing liver LPS level via the TLR4/NF-κB pathway and intestinal microbiota, revealing that red rice seed coat holds potential as a functional food for the prevention and treatment of ALD. Full article
(This article belongs to the Special Issue Alcohol Intake and Human Health)
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