Special Issue "Polymer Nanoparticles for Delivery of Therapeutic Proteins"
Deadline for manuscript submissions: 28 February 2022.
2. iBB - Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal
Interests: drug delivery; nanomedicine; protein delivery; protein characterization; freeze-drying; biopharmaceutical; tissue engineering; wound healing; biomaterials; translational medicine
Special Issues and Collections in MDPI journals
Therapeutic proteins have been attracting great attention in drug development, due to thei importance in treating severe health problems and diseases, such as cancer, genetic disorders, exposure to infectious agents, and autoimmune or inflammatory conditions. They are advantageous over conventional drugs, mainly due to their superior bioactivity and specificity, which improves the therapy outcome and decreases the probability of possible side-effects. However, the delivery of therapeutic proteins is challenging because they are prone to suffer instability caused by external factors like harsh pH, enzymatic degradation, and others, hampering their bioactivity and half-life in the body. Further, the uptake of therapeutic proteins through biological barriers is very challenging, due to their high molecular weight.
The encapsulation of therapeutic proteins into nanoparticles comes to the front line as a strategy to overcome the problems associated with therapeutic protein delivery. Among the different encapsulating materials found in the literature, polymers both from natural and synthetic sources are some of the most important ones due to their versatility, biocompatibility, biodegradability, and ability to tailor the production of nanoparticles. Polymer nanoparticles are optimal materials for therapeutic protein delivery because they can protect the structure of the loaded protein, to deliver it in a sustained, controlled or targeted manner, and to promote the uptake of proteins through biological barriers. Furthermore, the combination of polymer nanoparticles with other encapsulating materials and excipients such as protease inhibitors and permeation enhancers have been demonstrated to be a good strategy, to enhance the bioavailability of therapeutic proteins and improve the treatment of several diseases.
Overall, this Special Issue aims to provide an overview of the recent advances on the delivery of therapeutic proteins using polymer nanoparticles, focusing on promising strategies that allow improving therapies and patients’ quality of life.
As Guest Editor, I cordially invite all researchers to contribute in the form of original research articles or reviews in this important and exciting research field.
Dr. Pedro Fonte
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- polymer nanoparticle
- drug delivery
- therapeutic protein
- protein delivery
- protease inhibitor
- permeation enhancer
- polymer-protein interaction