Editorial Board Members’ Collection Series: New Insights into Neuroproteins

Dear Colleagues,

Owing to their complex structure, proteins are natural candidates for fulfilling key roles in cells and organs.

In particular, regardless of the often-unsuccessful outcomes in attempts to individuate proteins specific to the nervous system, which are specifically responsible for neural functions, these proteins (neuroproteins) have been shown to play roles which are especially relevant to this system.

Proteins such as S100B, Glial Fibrillary Acidic Protein, and Neuron-Specific Enolase have been shown to be useful cell markers. In addition, their levels in biological fluids are currently used to monitor neural disorders. Other molecules, such as alpha-synuclein and amyloid proteins, are regarded as hallmarks of several neurodegenerative disorders. Damage/Danger-Associated Molecular Pattern proteins and protein complex inflammasomes are also known to play a key role in neuroinflammatory processes, which is especially important in this system for their pathological implications. In this respect, specific receptors for these molecules are also obviously proteins in nature, such as the Receptor for Advanced Glycation-End Product and Toll-like Receptors in general.

This Special Issue will highlight novel findings in the form of original research articles or reviews dealing with different aspects of neuroprotein biology (in general and with reference to specific neuroproteins), including mechanistic insights and neuroproteins’ role in cells at the molecular level (e.g., gene expression and epigenetic studies, post-translational modifications, regulation of cell processes). Articles dealing with alterations in neuroproteins’ structure and function in human diseases, including their putative role(s) as pathological biomarkers and/or therapeutic targets, are especially welcome.

Prof. Dr. Barbara Mroczko
Prof. Dr. Fabrizio Michetti
Guest Editors

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• neuroproteins
• S100B
• glial fibrillary acidic protein
• neuron-specific enolase
• alpha-synuclein
• amyloid proteins