Topical Collection "Neuroinflammatory Processes in Neurodegenerative Diseases"
Interests: neurodegeneration; neuroinflammation; multiple sclerosis; amyotrophic lateral sclerosis; animal models of neural diseases; neural biomarkers; calcium-binding neuroproteins; S100B protein
Pathological conditions of the nervous system in which neurons degenerate are collectively defined as neurodegenerative diseases. Different diseases are developed, essentially depending on the location of the neuronal population(s) involved. Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, and multiple sclerosis are among the most pressing neurodegenerative diseases, owing to their devastating consequences. Despite the different aetiologies, a growing role is recognized in processes collectively referred to as neuroinflammation. During these processes neuron environment is affected, principally by non-neuronal neural cells, such as microglia and astrocytes, and also the blood–brain barrier, immune cells entering the nervous system, which mediate damage and repair. In this respect, emerging evidence also indicates that trillions of microorganisms that inhabit the gut (gut microbiota), may influence neuroinflammatory responses. They represent the most relevant source of proteins, pathogen-related motives, and “foreign” DNAs, continuously interacting with the immune system.
This Special Issue will provide an up-to-date overview, gathering research or review manuscripts addressing inflammatory processes that mechanistically participate to induce different neurodegenerative diseases, including molecular signaling pathways, mechanisms able to modulate immune cell trafficking, the role of microbiota, also considering the role of environment and genetics as drivers. Studies on inflammatory biomarkers as tools for diagnosing/monitoring neurodegenerative diseases are also welcome.
Prof. Dr. Fabrizio Michetti
Dr. Gabriele Di Sante
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- immune cells
- blood–brain barrier
- damage/danger-associated molecular patterns
- pattern recognition receptors
Jump to: 2020
Jump to: 2021