Dear Colleagues,

Over the last years bioactive lipids have emerged as clinically-relevant mediators of allergic disease pathophysiology. Compelling evidence suggests the importance of lipid mediators in the development of asthma, allergic rhinitis, atopic dermatitis, anaphylaxis, and food allergy. Lipids play key roles in cell signaling events, influencing physiologic (bronchial tone) and immune mechanisms (degranulation, chemotaxis, and sensitization) in allergic diseases. Lipids act through several cellular mechanisms such as the formation of structural support platforms (lipid rafts) for receptor signaling complexes, the activation of a diverse family of G-protein coupled receptors, and the mediation of intracellular signaling cascades by acting as second messengers. An increased understanding of these critical bioactive molecules will drive future innovations in treating atopy in its many forms. This Special Issue aims to shed light on and further the understanding of some of these intricate signaling mechanisms in allergic diseases. Specifically, we propose to explore and discuss the following points: (1) lipid synthesis pathways and signaling in atopic disease pathology; (2) the development of allergic disease treatments targeting lipid mediator pathways

Prof. Fiorentina Roviezzo
Guest Editor

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• atopy
• asthma
• immune inflammation
• sphingolipid
• leukotrienes
• anaphylaxis
• therapeutic targets
• food allergy