Special Issue "Circulating Tumor Cells: Pathological, Molecular and Functional Characteristics"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (29 February 2020).
Interests: circulating tumor cells; breast cancer; tumor heterogeneity; invasion
Special Issues and Collections in MDPI journals
Nowadays, therapeutic decisions are based overwhelmingly on the pathological and molecular characterization of the primary tumor. However, metastatic lesions can be highly heterogenous and substantially different from the primary neoplasm, which hampers the efficacy of the treatment. Moreover, the inaccessibility of metastatic foci and invasiveness of a biopsy represent challenging problems and call for some other means of secondary tumor characterization. Analysis of the circulating tumor cells (CTCs) as a surrogate for the metastatic lesion is non-invasive and allows for detailed characterization of the phenotype, genotype, heterogeneity, expression profiling and functional analysis of tumor cells. These data should have a direct impact on the diagnosis and decision-making related to adjuvant treatment by helping with patient stratification and should also provide valuable information about the biology of metastasis. This open-access Special Issue will bring together original research and review articles on CTCs, their biology, methods of enumeration and characterization, their role in metastasis and their predictive value for diagnostics and therapeutic applications. It will provide a platform to share new discoveries, approaches and technical developments in the field of CTC research and the development of the next generation of anti-metastasis treatments.
Topics of this Special Issue include, but are not limited to
- Diagnostic and therapeutic applications of CTC research;
- The biology of CTCs in different cancer types;
- CTC mobilization by treatment;
- Phenotypic/genotypic heterogeneity of CTCs;
- Technical developments in the isolation, enumeration and characterization of CTCs;
- Functional analysis of CTCs, including culture and CDX;
- CTC analysis in single cell resolution;
- Cell free DNA vs. CTC;
- Epithelial/hybrid/mesenchymal properties of CTCs;
- CTC clusters: biology, enumeration, role in metastasis.
Dr. Ewa A. Grzybowska
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor heterogeneity
- single cell analysis
- cancer dissemination
- treatment response
- CTC clusters