Dear Colleagues,

The increase in the life expectancy of the population imposes new challenges to understand how in some individuals brain aging is associated with a higher prevalence of neurodegenerative diseases, while in others, neuronal functions remain intact for much longer. It has been found that different factors contribute to pathological aging, including the management of oxidative damage and neuroinflammation, which are key to the development of neurodegenerative diseases. In this Special Issue, we are gathering manuscripts (reviews and articles) about the physiological and pathophysiological mechanisms for aging brain, such as, synaptic plasticity, calcium homeostasis, neuroinflammation, and reactive oxygen species, among others. A particular focus will be on the discovery of novel molecular mechanistic insights for a neurodegenerative disease treatment. 

Dr. Pablo Munoz
Dr. Roberta Fusco
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• neurodegenerative diseases
• huntington
• Alzheimer's disease (AD)
• molecular mechanism
• therapy