Special Issue "Nano-Strategies: The Future Medicine for Fighting Cancer Progression and Drug Resistance"
Deadline for manuscript submissions: closed (29 February 2020).
Interests: cancer research; cancer chemotherapy; molecular biology; cell biology; pharmacology; nanomedicine; drug discovery
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The administration of conventional antitumor therapy is the first choice in clinical practice for patients suffering from disseminated tumors. Unfortunately, the development of drug resistance and systemic toxicity often require the suspension of treatment and lead to tumor progression and patients’ deaths. Among the several strategies considered to counteract drug resistance, the encapsulation of the drugs into nanovectors appears very promising. Importantly, their capability demonstrated in protecting cargo makes nanodevices useful for the delivery of therapeutic nucleic acids, a field of research that has increased significantly in recent years. Despite numerous studies that have proved the efficacy of nanosystems in (i) carrying a large therapeutics “payload”; (ii) accommodating multiple drug molecules that simultaneously enable combinatorial cancer therapy and bypass well-known drug resistance mechanisms; and (iii) targeting specific cells/tissues through the multivalent targeting ligands, which yield high affinity and specificity, only a limited number of nanodevices have attained clinical success (e.g., Doxil and Abraxane). These features imply that additional efforts are required before nanomedicine supplants conventional drug delivery administration. In this Special Issue, we welcome contributions, reviews, and original articles focused on all the aspects embraced by nanostrategies and adopted for combating cancer progression and drug resistance.
Dr. Giovanni L. Beretta
Manuscript Submission Information
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- Antitumor drugs
- Tumor progression
- Drug resistance
- Drug delivery