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Special Issue "Redox Modulation: Biological and Therapeutical Implication"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 January 2021).

Special Issue Editors

Assoc. Prof. Dr. Claudio Santi
Website
Guest Editor
Professor of Organic Chemistry at Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy
Interests: organic synthesis; selenium chemistry; catalysis; bioorganic redox; green chemistry
Special Issues and Collections in MDPI journals
Dr. Luca Sancineto

Guest Editor
Department of Heteroorganic Chemistry, Center of Molecular and Macromolecular Studie of the Polish Academy of Sciences, Lódz, Poland
Interests: Medicinal Chemistry; Chemistry of Organoselenium Compounds; Redox Catalysis

Special Issue Information

Dear Colleagues,

Redox reactions are involved in several biochemical pathways, playing a key role in both physiological and pathological events. Redox equilibria in living systems, as well as the modulation of the redox signaling, are even more frequently studied as targets for a novel class of therapeutic compounds, and to explain the mechanism of several pathologies. All contributions focused in the field will be welcome in this Special Issue, with particular interest on the development of new redox modulators, and drugs acting via redox mechanisms. We will also appreciate new insights into the molecular mechanisms of redox enzymes and proteins, and their mimetics.

Prof. Dr. Claudio Santi
Dr. Luca Sancineto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessCommunication
PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity
Int. J. Mol. Sci. 2019, 20(9), 2121; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms20092121 - 29 Apr 2019
Cited by 2
Abstract
We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, [...] Read more.
We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation. Full article
(This article belongs to the Special Issue Redox Modulation: Biological and Therapeutical Implication)
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