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Special Issue "The Role of Vitamin D in Human Health and Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 15 August 2021.

Special Issue Editors

Dr. Loredana Bergandi
E-Mail Website
Guest Editor
Department of Oncology, University of Torino, via Santena 5 bis, 10126 Torino, Italy
Interests: nitric oxide; oxidative/nitrosative stress; in vitro bioglass compatibility; asbestos; epithelial–mesenchymal transition; oocytes competence; metabolic shift; chemoresistance
Prof. Dr. Francesca Silvagno
E-Mail Website
Co-Guest Editor
Department of Oncology, University of Torino, via Santena 5 bis, 10126 Torino, Italy
Interests: cancer metabolism; vitamin D; TGF beta; mitochondrial metabolism; biochemistry; electromagnetic field; cancer growth; dermal wound healing; nutraceuticals

Special Issue Information

Dear Colleagues,

Vitamin D has been described as a differentiative hormone, but this definition is reductive for a molecule targeting every tissue, produced in its active form by many kinds of cell and effective over the whole life of a cell by means of different mechanisms, which lead to nuclear, non-genomic, and mitochondrial effects. In fact, vitamin D not only controls the transcription of thousands of genes, directly or indirectly through the modulation of calcium fluxes, but it also influences cell metabolism to support specific nuclear programs. Given its broad spectrum of activity and molecular and cellular targets, it is not surprising that the deficiency of vitamin D is involved in many pathologies. In addition to its well-known impact on several functions, such as bone remodeling, skin differentiation, and the immune system, to cite just a few, many other tissues depend heavily on vitamin D for their health, and therefore the correlation between low levels of vitamin D and the onset of many diseases has been reported. However, many other links could be revealed. For example, considering the current COVID-19 pandemic, a recent discovery showed that a deficiency of vitamin D is among the risk factors associated with the severity of COVID-19 symptoms and outcome.

In vitro studies and those in animal models have demonstrated the efficacy of vitamin D treatment in many models of disease and have proposed the beneficial effects of vitamin D supplementation on health and prevention, as well as the regression of multiple diseases. As a result, several clinical trials are testing the efficacy of vitamin D supplementation in human disfunctions; although some results are encouraging, few discrepancies can be due to differences in therapy protocols and resistance to the hormone, and in general can be explained by an individual sensitivity to its action. More studies, both in vitro and in vivo, are needed to verify the mechanisms involved in successful or failed treatment with vitamin D, and further investigation is essential to set out an approach from bench to bedside, underlying personalized medicine.

This Special Issue gives insights into the evolving field of vitamin D regarding its mechanisms of action, causes of deficit, proper supplementation, health benefits, and clinical applications.

Dr. Loredana Bergandi
Guest Editor
Prof. Dr. Francesca Silvagno
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Vitamin D

vitamin D receptor

health

disease

inflammation

gene transcription

cell metabolism

differentiation

vitamin D deficiency

vitamin D supplementation

Published Papers (1 paper)

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Research

Article
Vitamin D Supplementation: Oxidative Stress Modulation in a Mouse Model of Ovalbumin-Induced Acute Asthmatic Airway Inflammation
Int. J. Mol. Sci. 2021, 22(13), 7089; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22137089 - 30 Jun 2021
Viewed by 407
Abstract
Asthma oxidative stress disturbances seem to enable supplementary proinflammatory pathways, thus contributing to disease development and severity. The current study analyzed the impact of two types of oral vitamin D (VD) supplementation regimens on the redox balance using a murine model of acute [...] Read more.
Asthma oxidative stress disturbances seem to enable supplementary proinflammatory pathways, thus contributing to disease development and severity. The current study analyzed the impact of two types of oral vitamin D (VD) supplementation regimens on the redox balance using a murine model of acute ovalbumin-induced (OVA-induced) asthmatic inflammation. The experimental prevention group received a long-term daily dose of 50 µg/kg (total dose of 1300 µg/kg), whereas the rescue group underwent a short-term daily dose of 100 µg/kg (total dose of 400 µg/kg). The following oxidative stress parameters were analyzed in serum, bronchoalveolar lavage fluid (BALF) and lung tissue homogenate (LTH): total oxidative status, total antioxidant response, oxidative stress index, malondialdehyde and total thiols. Results showed that VD significantly reduced oxidative forces and increased the antioxidant capacity in the serum and LTH of treated mice. There was no statistically significant difference between the two types of VD supplementation. VD also exhibited an anti-inflammatory effect in all treated mice, reducing nitric oxide formation in serum and the expression of nuclear factor kappa B p65 in the lung. In conclusion, VD supplementation seems to exhibit a protective role in oxidative stress processes related to OVA-induced acute airway inflammation. Full article
(This article belongs to the Special Issue The Role of Vitamin D in Human Health and Diseases)
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