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Special Issue "Novel In Vitro and In Silico Approaches to Study Developmental Neurotoxicity"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 August 2021.

Special Issue Editor

Dr. David Pamies
E-Mail Website
Guest Editor
Department of Biomedical Science, University of Lausanne, Lausanne, Switzerland
Interests: neurology; neurotoxicology; developmental neurotoxicology; organoids; in vitro brain models; glioblastoma

Special Issue Information

Dear Colleagues,

There are sufficient shreds of evidence that increased exposure to environmental contaminants plays a substantial role in the increase in developmental diseases. Due to the complexity of the brain, this organ ishighly vulnerable to toxic insult. Current developmental neurotoxicity (DNT) testing guidelines present high cost and are very time consuming, generating a lack of information and knowledge concerning  new chemicals reaching the market. DNT experts have suggested changing/updating current testing guidelines with a comprehensive in vitro DNT strategy, consisting of a test battery that recapitulates key events during brain development. A DNT screening program has been developed under EFSA, the JRC, the US EPA, and the OECD to develop a complete DNT testing battery that could replace the actual guidelines OECD TG 426 or OECD TG 443.

The special issue aims to cover original research and reviews focused on new advances in in vitro and in silico neurotoxicity testing strategies and models which in the future could be used or further adapt for developmental neurotoxicology studies.

Dr. David Pamies
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurotoxicity
  • developmental neurotoxicity
  • in vitro assay
  • alternatives to animal teting

Published Papers

This special issue is now open for submission.
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