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Special Issue "The Effects of Natural Compounds in Cell Differentiation and Signaling Pathways"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. See-Hyoung Park
E-Mail Website1 Website2
Guest Editor
Department of Biological and Chemical, Hongik University, Sejong, Korea
Interests: natural compounds; chemical genomics; functional foods; cosmeceuticals; cancer biology
Special Issues and Collections in MDPI journals

Special Issue Information

Dear colleagues

Phytochemicals are natural compounds produced by many kinds of plants, and their function is generally to help them thrive or thwart predators or pathogens. It is reported that there are several beneficial effects of phytochemicals on human health such as anti-cancer, anti-immune-response, anti-bacterial, and antioxidant effects. Over the last ten years, phytochemicals have been widely investigated to develop effective medicines for the treatment of various diseases because of their high efficacy and minimal side effects.

In this specific issue, we are gathering manuscripts (reviews and articles) about the regulation of cellular processes and signaling pathways by novel phytochemicals that could be applied to the development of functional foods (nutraceuticals), functional cosmetics (cosmeceuticals), and even medicines.

Dr. See-Hyoung Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive
  • nutraceuticals
  • cosmeceuticals
  • functional foods
  • functional cosmetics
  • medicinal plants
  • signaling pathway
  • inhibitor
  • activator
  • cell differentiation

Published Papers (1 paper)

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Review

Review
Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?
Int. J. Mol. Sci. 2021, 22(15), 8223; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22158223 - 30 Jul 2021
Cited by 1 | Viewed by 536
Abstract
Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and angiogenesis processes. Therefore, they are involved in many steps of carcinogenesis through cooperation with multiple signaling molecules and pathways. [...] Read more.
Nrf2 (nuclear factor erythroid 2-related factor 2) and NF-κB (nuclear factor–kappa B) signaling pathways play a central role in suppressing or inducing inflammation and angiogenesis processes. Therefore, they are involved in many steps of carcinogenesis through cooperation with multiple signaling molecules and pathways. Targeting both transcription factors simultaneously may be considered an equally important strategy for cancer chemoprevention and therapy. Several hundreds of phytochemicals, mainly edible plant and vegetable components, were shown to activate Nrf2 and mediate antioxidant response. A similar number of phytochemicals was revealed to affect NF-κB. While activation of Nrf2 and inhibition of NF-κB may protect normal cells against cancer initiation and promotion, enhanced expression and activation in cancer cells may lead to resistance to conventional chemo- or radiotherapy. Most phytochemicals, through different mechanisms, activate Nrf2, but others, such as luteolin, can act as inhibitors of both Nrf2 and NF-κB. Despite many experimental data confirming the above mechanisms currently, limited evidence exists demonstrating such activity in humans. Combinations of phytochemicals resembling that in a natural food matrix but allowing higher concentrations may improve their modulating effect on Nrf2 and NF-κB and ultimately cancer prevention and therapy. This review presents the current knowledge on the effect of selected phytochemicals and their combinations on Nrf2 and NF-κB activities in the above context. Full article
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