Ubiquitination and Deubiquitination in Cellular Homeostasis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 81302
Special Issue Editor
Interests: deubiquitinating enzyme; cell proliferation; apoptosis; ubiquitin-specific protease; signal transduction
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For cellular homeostasis, the regulation of selective proteolysis is largely mediated by post-translational modification with coordinated addition and removal of ubiquitin by the ubiquitin–proteasome system. Both ubiquitination and deubiquitination regulate the stability or cellular functions of proteins, allowing regulation of protein turnover, diverse signaling pathways, DNA damage response, etc. Dysregulation of these cellular processes is increasingly being identified as a causative in various human diseases, such as cancers, metabolic diseases, neurodegenerative disorders, and so on. Therefore, a better understanding of the molecular mechanisms in cellular homeostasis will provide new insights into the development of more specific therapeutic approaches.
This Special Issue of the International Journal of Molecular Sciences will focus on the role of ubiquitination and deubiquitination, including new insights into diverse cellular processes. Articles submitted can either be original research works regarding these processes or full reviews; however, we kindly encourage authors to provide short and highly focused reviews on specific and hot topics related to cellular homeostasis.
Prof. Dr. Kwang-Hyun Baek
Guest Editor
Manuscript Submission Information
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Keywords
- deubiquitination
- homeostasis
- post-translational modification
- proteasomal degradation
- protein quality control
- proteolysis
- signaling pathway
- small molecule
- ubiquitin–proteasome system
- ubiquitination