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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunity, Inflammation, and Injury in the Pathogenesis and Progression of Kidney Diseases—from Bench to Bedside submission deadline 30 Sep 2024 | Viewed by 380 | Submission Open
Keywords: systemic immune inflammation index; neutrophil extracellular traps; pathogen associated molecular  patterns; damage associated molecular patterns; complement system; stress proteins; acute kidney injury; tubular damage; chronic kidney disease; hypertension; glomerulopathy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nano & Micro Materials in Healthcare 3.0
edited by
submission deadline 30 Sep 2024 | 1 articles | Viewed by 363 | Submission Open
Keywords: biomaterials; theranostics; therapeutics; drug delivery; nanomedicine; precision medicine; regenerative medicine; diagnostics; toxicology; vaccines; cancer; cardiovascular disease; immunotherapy; gene therapy; infectious disease therapy; tissue engineering; imaging; implants; nano/microfluidics; targeting; translational medicine; biosensors
(This special issue belongs to the Section Macromolecules)
Modeling Neurological Disorders in Experimental Animals: New Insights and Emerging Roles 4.0
edited by
submission deadline 30 Sep 2024 | 1 articles | Viewed by 357 | Submission Open
Keywords: neurological disorders; animal models; developmental models; genetic models; molecular mechanisms; genetic analysis; drug efficacy testing
(This special issue belongs to the Section Molecular Neurobiology)
Periodontitis: Advances in Mechanisms, Treatment and Prevention
edited by
submission deadline 30 Sep 2024 | 1 articles | Viewed by 346 | Submission Open
Keywords: periodontitis; genetic; epigenetic; signaling pathways; therapeutic target; precision dentistry; non-surgical periodontal treatment; systemic diseases; oral microbiome; risk factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thyroid Disorders and Cancers: Molecular Mechanisms and Advanced Therapies
edited by
submission deadline 30 Sep 2024 | 1 articles | Viewed by 336 | Submission Open
Keywords: autoimmune thyroid disease; hypothyroidism; residual thyroid symptoms; thyroid nodules; thyroid cancer; radioiodine refractory-differentiated thyroid cancer; drug discovery; novel treatments; standard of care
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Bioinformatics Analysis of Protein Properties submission deadline 30 Sep 2024 | Viewed by 331 | Submission Open
Keywords: protein properties; bioinformatics; structural bioinformatics; next-generation sequence; drug design; deep learning; phylogeny; protein functions; molecular modeling; molecular docking; molecular dynamics
(This special issue belongs to the Section Molecular Informatics)
G Protein-Coupled Receptors in Cell Signaling Transductions 2.0 submission deadline 30 Sep 2024 | Viewed by 306 | Submission Open
Keywords: GPCRs; G-Proteins; canonical/non-canonical signaling; AGS proteins; RGS proteins; β -arrestin; NDPKs; pharmacological intervention; biased ligands
(This special issue belongs to the Section Biochemistry)
Paradigm Shift in Central Nervous System Trauma: Molecular Targets and New Therapeutic Strategies submission deadline 30 Sep 2024 | Viewed by 275 | Submission Open
Keywords: spinal cord injury; traumatic brain injury; regenerative medicine; neuronal plasticity; stem cell therapy; autoimmune antibodies; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Genomic Pathology
edited by Lucas Santana-Santos
submission deadline 30 Sep 2024 | Viewed by 256 | Submission Open
Keywords: genomics; pathology; molecular pathology; next generation sequencing; bioinformatics; artificial intelligence; personalized medicine; oncology; digital pathology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Investigation of Heart Disease submission deadline 30 Sep 2024 | Viewed by 250 | Submission Open
Keywords: heart failure; cardiomyopathy; molecular cardiology; cardiac signaling; single-cell sequencing; multi-OMICS
(This special issue belongs to the Section Molecular Biology)
Ocular Ischemic Diseases: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 30 Sep 2024 | Viewed by 248 | Submission Open
Keywords: diabetic retinopathy; retinopathy of prematurity; retinal vein occlusion; retinal artery occlusion; pathologic myopia; age-related macular degeneration; glaucoma; ocular ischemic syndrome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds, Vitamins, and Polyphenols in Cardiovascular and Metabolic Protection
edited by Dragan M. Djuric
submission deadline 30 Sep 2024 | Viewed by 245 | Submission Open
Keywords: cardiovascular protection; metabolic protection; natural compounds; polyphenols; vitamins
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Changes and Adaptations of the Plant Metabolism under Elemental Nutrient Deficiencies
edited by Li Rui
submission deadline 30 Sep 2024 | Viewed by 244 | Submission Open
Keywords: nutrient elements; plant metabolism; tolerance; plant molecular responses  
(This special issue belongs to the Section Molecular Plant Sciences)
Impact of Signaling Pathways on Endothelial Cells: From Homeostasis to Disease
edited by
submission deadline 30 Sep 2024 | Viewed by 239 | Submission Open
Keywords: endothelial cells; signaling pathways; endothelial homeostasis; vascular diseases; vascular malformations; lymphatic malformations; endothelial heterogeneity; intercellular communication
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Novel Therapeutic Strategies for Gynecological Cancer: Molecular Biological Insights
edited by Jiantai Timothy Qiu
submission deadline 30 Sep 2024 | Viewed by 228 | Submission Open
Keywords: gynecological cancers; cervical cancer; uterine cancer; ovarian cancer; fallopian tube cancer; peritoneal cancer and vulvar cancer; targeted therapy; immunotherapy; epigenetic modulator; cancer vaccines and cell therapy; molecular profiling and personalized medicine
(This special issue belongs to the Section Molecular Oncology)
Machine Learning Applications in Bioinformatics and Biomedicine 2.0
edited by Hao Lv
submission deadline 30 Sep 2024 | Viewed by 203 | Submission Open
Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetics markers discovery for disease; molecular network marker; early screening of diseases
(This special issue belongs to the Section Molecular Informatics)
Oral Cancer: Update on Molecular Pathology, Mechanisms and Treatments
edited by
submission deadline 30 Sep 2024 | Viewed by 202 | Submission Open
Keywords: oral cancer; mechanisms of incidence and development of oral cancer; metastasis; diagnosis; biomarkers; treatments (active ingredients; medicines; biomedicines; and gene therapy)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurodegenerative Diseases and Protein Quality Control System
edited by Abdullah Sheikh
submission deadline 30 Sep 2024 | Viewed by 202 | Submission Open
Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; Huntington’ s disease; autophagy; protein aggregation; ubiquitin– proteasome system; neurodegeneration; neuroinflammation; aggregated protein clearance
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance submission deadline 30 Sep 2024 | Viewed by 192 | Submission Open
Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Mitochondria in Human Health and Disease
edited by
submission deadline 30 Sep 2024 | Viewed by 182 | Submission Open
Keywords: mitochondria; mitochondrial DNA; metabolism; aging; mitochondrial disorders; human cancers; biomarker; therapeutics; mitochondrial pathways
(This special issue belongs to the Section Molecular Biology)
Recent Advances of Natural Products in Chemical and Biological Aspects submission deadline 30 Sep 2024 | Viewed by 179 | Submission Open
Keywords: bioactive compounds; polyphenols; antioxidants; natural products; phytochemicals; molecular research; chemical composition; therapeutic targets; action mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Antioxidants and Enzyme Inhibitors: Design, Synthesis and Action Mechanisms submission deadline 30 Sep 2024 | Viewed by 178 | Submission Open
Keywords: antioxidants; bioactive compounds; oxidative stress; reactive oxygen species; enzyme inhibition
(This special issue belongs to the Section Biochemistry)
Advances in Genetics of Human Reproduction submission deadline 30 Sep 2024 | Viewed by 170 | Submission Open
Keywords: genetic; human reproduction; infertility; medically assisted reproduction; pregnancy complications; recurrent miscarriage
(This special issue belongs to the Section Molecular Genetics and Genomics)
Multiple Sclerosis and the Neuroinflammation
edited by
submission deadline 30 Sep 2024 | Viewed by 168 | Submission Open
Keywords: multiple sclerosis; neuroinflammation; immune system; pathogenesis; therapeutic targets; experimental approaches; organoids; neurodegeneration; demyelination; auto-antibodies  
(This special issue belongs to the Section Molecular Neurobiology)
Selected Papers for the 30th International Conference on Chelation (ICOC)—a Landmark on Metal Chelation Science and Medicine submission deadline 30 Sep 2024 | Viewed by 167 | Submission Open
Keywords: chelation therapy; metals in medicine; free radicals; ferroptosis; antioxidants; anticancer drugs; thalassaemia; other iron metabolic disorders; antimicrobials; drug design; nutraceuticals; metal complexes; diagnostic and theranostics
(This special issue belongs to the Section Molecular Pharmacology)
Protein–RNA Interactions: Function, Mechanism, and Identification
edited by
submission deadline 30 Sep 2024 | Viewed by 152 | Submission Open
Keywords: RNA-binding protein (RBP); protein– RNA interaction; RNA structure; RNA processing; RNA stability; RNA modification; translation; gene regulatory network
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Syndrome: New Insights in Pathogenesis, Diagnosis, Prevention, and Management submission deadline 30 Sep 2024 | Viewed by 150 | Submission Open
Keywords: insulin resistance; hypertension; diabetes mellitus; obesity; inflammation; stress; metabolic disorders; reproductive endocrine disorders; polycystic ovarian syndrome; waist circumference; estrogen deficiency; disturbances in adipose tissue; physical inactivity; overnutrition; cardiovascular diseases; abdominal obesity; genetics and epigenetics of metabolic syndrome; computational analysis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
From Biomolecules to Therapies: Bridging the Gap with Molecular Mechanisms, Computational Design, and Drug Delivery submission deadline 30 Sep 2024 | Viewed by 147 | Submission Open
Keywords: biomolecules; molecular mechanisms; computational studies; drug delivery; xenobiotics
(This special issue belongs to the Section Molecular Informatics)
Novel Metal Complexes for Biomedical Applications
edited by
submission deadline 30 Sep 2024 | Viewed by 142 | Submission Open
Keywords: metal complexes; therapeutic applications; anticancer agents; chemotherapeutic agents; antimicrobial applications; bacterial infections; fungal infections; anti-inflammatory effects; antioxidant effects; imaging agents; diagnostic applications; disease detection; disease monitoring; antimicrobial therapeutics; food safety
(This special issue belongs to the Section Biochemistry)
Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms
edited by
submission deadline 30 Sep 2024 | Viewed by 142 | Submission Open
Keywords: cell cycle; cell division; cyclins; cyclin-dependent kinases (CDKs); biochemical regulative mechanisms
(This special issue belongs to the Section Biochemistry)
The Biogenesis, Structure, Function and Division of Plastids
edited by and Li'na Yin
submission deadline 30 Sep 2024 | Viewed by 140 | Submission Open
Keywords: plastid; chloroplast; chlorophyll; endosymbiotic cyanobacteria; photosynthesis; genetic engineering
(This special issue belongs to the Section Biochemistry)
Application of Marine Bioactive Compounds in Disease Prevention
edited by and
submission deadline 30 Sep 2024 | Viewed by 140 | Submission Open
Keywords: marine bioactives; disease treatment; antioxidant; anti-inflammatory; new discovery of marine bioactive compounds
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Omics Era: From Principles to Applications in Disease Diagnosis and Treatment submission deadline 30 Sep 2024 | Viewed by 137 | Submission Open
Keywords: genomics; metagenomics; transcriptomics; proteomics; metabolomics; functional genomics; functional metagenomics; omics-based diagnostics
(This special issue belongs to the Section Molecular Informatics)
Nutrition as a Tool for Modulating Cellular Metabolism submission deadline 30 Sep 2024 | Viewed by 136 | Submission Open
Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology
(This special issue belongs to the Section Biochemistry)
Molecular Functions of Polyphenols in Health and Diseases submission deadline 30 Sep 2024 | Viewed by 135 | Submission Open
Keywords: natural products; polyphenols; biological activity; chromatography; antioxidants; cancer; cardiovascular diseases; diabetes; neurodegenerative disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Mechanisms in Biofilm Formation, Tolerance and Control 2.0
edited by and Lúcia Chaves Simões
submission deadline 30 Sep 2024 | Viewed by 135 | Submission Open
Keywords: adhesion; antimicrobial action; antimicrobial resistance; biofilm development; biofilm matrix; biofilm structure; quorum sensing; motility; surfaces
(This special issue belongs to the Section Molecular Microbiology)
Recent Developments in Omics Technologies Applied to Oncology Research
edited by
submission deadline 30 Sep 2024 | Viewed by 134 | Submission Open
Keywords: single‑cell genome sequencing; single‑cell epigenome sequencing; single‑cell CRISPR sequencing; imaging mass cytometry; RNAscope; digital spatial profiling; multiplex IHC; multiplex IF; omics technologies
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights into Plasma in Seed and Plant Treatment submission deadline 30 Sep 2024 | Viewed by 132 | Submission Open
Keywords: seed; plant; plasma; germination; dormancy; sterilization; reactive oxygen species; reactive nitrogen species; molecular mechanism; growth promotion; essential oils; plant stem cells; seed coating and pelleting
(This special issue belongs to the Section Molecular Plant Sciences)
Exploring the Complex Interplay between Metabolic Diseases, MASLD, and Liver Cancer submission deadline 30 Sep 2024 | Viewed by 129 | Submission Open
Keywords: hepatocellular carcinoma; MASLD; MASH; obesity; insulin resistance; dyslipidemia; liver cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Uncovering the Basis of Plant Nutrient Uptake, Interactions and Homeostasis: Molecular Mechanisms and Their Applications
edited by
submission deadline 30 Sep 2024 | Viewed by 129 | Submission Open
Keywords: nutrient transport; homeostasis; nutrient signaling and pathways; nitrogen use efficiency; acronutrients; micronutrients; plant nutrition
(This special issue belongs to the Section Molecular Plant Sciences)
Antimicrobial Resistance, Molecular Mechanisms and Fight Strategies 4.0 submission deadline 30 Sep 2024 | Viewed by 128 | Submission Open
Keywords: antimicrobial resistance; mechanisms of antimicrobial resistance; rapid antimicrobial-sensitive assays; drug discovery; antibiotics; vaccine; monoclonal antibodies; infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Research and Application of Platelet-Rich Plasma (PRP)
edited by
submission deadline 30 Sep 2024 | Viewed by 128 | Submission Open
Keywords: platelet-rich plasma; platelet-rich fibrin; platelets; exosome; mitochondria; growth factors; tissue regeneration
(This special issue belongs to the Section Molecular Biology)
The Characterization and Application of Enzymes in Bioprocesses
edited by Loredana Marcolongo
submission deadline 30 Sep 2024 | Viewed by 120 | Submission Open
Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing
(This special issue belongs to the Section Biochemistry)
A Commemorative Special Issue in Honor of Prof. Giovanni De Toni: A Pediatrician and Innovator at the Gaslini Children’s Hospital, Genoa, Italy
edited by , Angelo Ravelli and
submission deadline 30 Sep 2024 | Viewed by 119 | Submission Open
Keywords: bone; soft tissue sarcomas; neuroblastoma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytochrome P450 Mechanism and Reactivity
edited by
submission deadline 30 Sep 2024 | Viewed by 118 | Submission Open
Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition
(This special issue belongs to the Section Biochemistry)
Stem Cell Regenerative Medicine: From Molecular Basis to Translational Research
edited by Dongjun Lee
submission deadline 30 Sep 2024 | Viewed by 118 | Submission Open
Keywords: adult stem cells; embryonic stem cells; induced pluripotent stem cells; hematopoietic stem cells; hematological malignancy; regenerative medicine; cancer stem cells; niche; stem cell therapy; gene editing; CRISPR/Cas9; organoids
(This special issue belongs to the Section Molecular Biology)
Progress of Molecular Biology and Physiology in Silkworms submission deadline 30 Sep 2024 | Viewed by 117 | Submission Open
Keywords: silkworm; Bombyx mori; molecular biology; physiology; genome analysis; mode of action; genome editing  
(This special issue belongs to the Section Molecular Biology)
Rheumatoid Arthritis: Molecular Mechanisms and Immunotherapy
edited by Irena Manolova
submission deadline 30 Sep 2024 | Viewed by 117 | Submission Open
Keywords: rheumatoid arthritis; pathogenesis; innate immunity; adaptive immunity; inflammation; cytokines; autoantibodies; immunotherapy; clinical outcome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Medicinal Mechanism and Application of Biologically Active Compounds in Melanoma
edited by Rosanna Avola and Adriana C. E. Graziano
submission deadline 30 Sep 2024 | Viewed by 114 | Submission Open
Keywords: biologically active compounds; medicinal mechanism; cancer; melanoma; chemoprevention; anticancer effect; immunomodulation; apoptosis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Challenges and Future Perspectives in Treatment for Lung Cancer
edited by Ilaria Marrocco and
submission deadline 30 Sep 2024 | Viewed by 114 | Submission Open
Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery
(This special issue belongs to the Section Molecular Oncology)
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