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Nutrients
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Nutrition for the Prevention and Control of Chronic Degenerative Diseases...
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Nutrition for the Prevention and Control of Chronic Degenerative Diseases and COVID-19

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 5780

Special Issue Editor

Dr. Laura Di Renzo

E-Mail Website
Guest Editor
Division of Human Nutrition, Department of Neuroscience, University of Rome Tor Vergata, Via Montpellier n. 1, 00183 Rome, Italy
Interests: nutritional genomic (nutrigenetic and nutrigenomic); human body composition; metabolism; personalized nutritional assessment; food chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic degenerative diseases (CDDs), represented by non-infectious diseases with a long duration and slow progression, including obesity, heart disease, diabetes, neurodegenerative diseases, chronic respiratory diseases, and cancer, are the most frequent causes of prolonged disability and death worldwide.

Patients with one or more CDD represent over 30% of the global population, and 70% of public health resources are dedicated to these diseases. In the meantime, infectious diseases caused by emerging pathogens, such as SARS-Coronavirus 2 (SARS-CoV-2), represent a real and current threat at global level.

The relationship between CCDs and viral infection susceptibility is undeniable. Following the emergence of COVID-19, recent publications have demonstrated that the most serious clinical conditions in COVID-19 patients have been observed in people with obesity and metabolic dysfunction, as well as in protein-energetic malnourishment and micronutrient deficiencies.  

Considering the sanitary expenditures of each continent, it is necessary to formulate a multidisciplinary strategy to fight the depletion of individual health status, predisposition to viral infection, and other exogenous risk factors. A nutritional strategy is thus urgently needed to prevent and control CDDs and COVID-19.

Authors are invited to submit original research and review articles that address the progress and current understanding of the role of personalized healthy and sustainable diet in CDD and COVID-19.

Potential topics include (but are not limited to):

  • The role of healthy diet in chronic noncommunicable disease and COVID-19;
  • Food sustainability and COVID-19;
  • Personalized nutrition and COVID-19;
  • Immunonutrition and COVID-19;
  • The role of prebiotics and probiotics on gut microbiota and COVID-19;
  • Effects of bioactive molecules.

Dr. Laura Di Renzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COVID-19
  • chronic degenerative diseases
  • immunonutrition
  • vitamin and minerals
  • probiotic and prebiotic
  • anti-inflammatory and antioxidant compounds
  • nutrigenetics and nutrigenomics
  • obesity
  • nutraceuticals

Published Papers (3 papers)

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Research

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22 pages, 542 KiB  
Article
Effectiveness of Nutritional Supplements for Attenuating the Side Effects of SARS-CoV-2 Vaccines
by Paola Gualtieri, Domenico Trombetta, Antonella Smeriglio, Giulia Frank, Angela Alibrandi, Giulia Leggeri, Marco Marchetti, Ilaria Zingale, Silvia Fanelli, Arianna Stocchi and Laura Di Renzo
Nutrients 2023, 15(8), 1807; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15081807 - 07 Apr 2023
Cited by 2 | Viewed by 2759
Abstract
Supplementation is known to enhance the immune response and reduce infection. Therefore, the association between immune nutrients and vaccine side effects needs to be investigated. Our aim was to analyze the relationship between vaccination side effects and supplement intake among the Italian population. [...] Read more.
Supplementation is known to enhance the immune response and reduce infection. Therefore, the association between immune nutrients and vaccine side effects needs to be investigated. Our aim was to analyze the relationship between vaccination side effects and supplement intake among the Italian population. The study included a questionnaire asking for personal data, anthropometric information, COVID-19 infection and immunity response, and COVID-19 vaccination and supplementation. The survey was conducted from 8 February to 15 June 2022. In the study, 776 respondents were included, aged between 18 and 86 (71.3% females). We observed a statistically significant correlation between supplement consumption and side effects at the end of the vaccination cycle (p = 0.000), which was also confirmed by logistic regression (p = 0.02). Significant associations were observed between supplement intake and side effects of diarrhea and nausea at the end of the vaccination cycle (p = 0.001; p = 0.04, respectively). Significant associations were observed between side effects and omega-3 and mineral supplementation at the start of the vaccination cycle (p = 0.02; p = 0.001, respectively), and between side effects and vitamin supplementation at the end of the vaccination cycle (p = 0.005). In conclusion, our study shows a positive impact of supplementation on vaccination response, increasing host immune defenses, and reducing side effects. Full article
(This article belongs to the Special Issue Nutrition for the Prevention and Control of Chronic Degenerative Diseases and COVID-19)
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Review

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19 pages, 671 KiB  
Review
Pancreatic Ductal Adenocarcinoma and Nutrition: Exploring the Role of Diet and Gut Health
by Paola Gualtieri, Rossella Cianci, Giulia Frank, Erica Pizzocaro, Gemma Lou De Santis, Silvia Giannattasio, Giuseppe Merra, Giovanni Butturini, Antonino De Lorenzo and Laura Di Renzo
Nutrients 2023, 15(20), 4465; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15204465 - 21 Oct 2023
Cited by 1 | Viewed by 1742
Abstract
The incidence of pancreatic cancer is increasing worldwide. The most common form is represented by pancreatic ductal adenocarcinoma (PDAC) which has been shown to be linked to chronic inflammation. Notably, the gut microbiota has emerged as a critical player in regulating immune responses [...] Read more.
The incidence of pancreatic cancer is increasing worldwide. The most common form is represented by pancreatic ductal adenocarcinoma (PDAC) which has been shown to be linked to chronic inflammation. Notably, the gut microbiota has emerged as a critical player in regulating immune responses and inflammation. Indeed, intestinal dysbiosis, characterized by an imbalance in the gut microbiota composition, can contribute to the initiation of chronic inflammation. Sterile chronic inflammation can occur, probably activated by the translocation of bacterial components, such as lipopolysaccharide (LPS), the major component of Gram-negative microbiota, with the consequent induction of innate mucosal immunity, through the activation of Toll-like receptors (TLRs). Furthermore, the interaction between LPS and TLRs could enhance cancer progression. Recent research has shed light on the pivotal role of nutrition, as a modifiable risk factor, in PDAC immunological processes, particularly focusing on the immuno-modulatory effects of the gut microbiota. Different dietary regimens, fiber intake, immunonutrients, and antioxidants have the potential to either exacerbate or mitigate chronic inflammation, thereby influencing the pathogenesis and natural history of PDAC. These dietary components may affect the gut microbiota composition and, consequently, the level of inflammation, either promoting or protecting against PDAC. In this review of reviews, we discuss the modulatory role of nutrition and the gut microbiota in PDAC’s immunological processes to explore a translational therapeutic approach that could improve the survival and quality of life of these patients. Full article
(This article belongs to the Special Issue Nutrition for the Prevention and Control of Chronic Degenerative Diseases and COVID-19)
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15 pages, 1325 KiB  
Review
Exploring the Network between Adipocytokines and Inflammatory Response in SARS-CoV-2 Infection: A Scoping Review
by Ersilia Nigro, Vito D’Agnano, Gianluca Quarcio, Domenica Francesca Mariniello, Andrea Bianco, Aurora Daniele and Fabio Perrotta
Nutrients 2023, 15(17), 3806; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15173806 - 30 Aug 2023
Cited by 2 | Viewed by 890
Abstract
Adipose tissue is actually regarded as an endocrine organ, rather than as an organ that merely stores energy. During the COVID-19 pandemic, obesity has undoubtedly emerged as one of the most important risk factors for disease severity and poor outcomes related to SARS-CoV-2 [...] Read more.
Adipose tissue is actually regarded as an endocrine organ, rather than as an organ that merely stores energy. During the COVID-19 pandemic, obesity has undoubtedly emerged as one of the most important risk factors for disease severity and poor outcomes related to SARS-CoV-2 infection. The aberrant production of cytokine-like hormones, called adipokines, may contribute to alterations in metabolism, dysfunction in vascular endothelium and the creation of a state of general chronic inflammation. Moreover, chronic, low-grade inflammation linked to obesity predisposes the host to immunosuppression and excessive cytokine activation. In this respect, understanding the mechanisms that link obesity with the severity of SARS-CoV-2 infection could represent a real game changer in the development of new therapeutic strategies. Our review therefore examines the pathogenic mechanisms of SARS-CoV-2, the implications with visceral adipose tissue and the influences of the adipose tissue and its adipokines on the clinical behavior of COVID-19. Full article
(This article belongs to the Special Issue Nutrition for the Prevention and Control of Chronic Degenerative Diseases and COVID-19)
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