Special Issue "The Role of Dietary Whole Grain and Its Phytochemicals in Diabetes, Insulin Resistance and Obesity"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: 10 March 2022.

Special Issue Editor

Prof. Dr. Qun Shen
E-Mail Website
Guest Editor
National Center of Technology Innovation (Deep Processing of Highland Barley) in Food Industry, Key Laboratory of Plant Protein and Grain Processing, National Engineering and Technology Research Center for Fruits and Vegetables, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
Interests: whole grain; phytochemicals; obesity; diabetes; health benefits; synergistic or antagonistic action

Special Issue Information

Dear Colleagues,

I am honored to have the opportunity to invite you to contribute your research work to Nutrients.

Whole grains are considered part of a healthy and sustainable diet because they can contribute to maintaining a healthy weight; reduce the risk of cardiovascular disease, type 2 diabetes, and bowel cancer; and promote the stability and diversity of intestinal flora, thereby reducing the risk of intestinal diseases. Many countries around the world encourage their residents to consume as much whole grains as possible.

This special issue in order to provide readers with more information about different varieties of whole grains and the role of their phytochemicals in the health benefits attributed to these foods. The goal of this Special Issue is to highlight novel research findings on reducing the risk of cardiovascular disease, type 2 diabetes, metabolism modulation, gut microbiota dysbiosis, etc.

We welcome submissions of original research articles, reviews, and mini-reviews focusing on but not limited to the following topics:

  • Animal and clinical studies on dietary whole grains and their phytochemicals and their influence on abnormal glucose metabolism, lipid metabolism, gut microbiota, and any other relevant health outcomes.
  • Synergistic or antagonistic action between different whole grains or their phytochemicals on metabolism modulation and gut microbiota dysbiosis.

Prof. Dr. Qun Shen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • whole grains
  • phytochemicals
  • obesity
  • diabetes
  • health benefits
  • synergistic or antagonistic action

Published Papers (1 paper)

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Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice
Nutrients 2021, 13(9), 3240; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093240 - 17 Sep 2021
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Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki [...] Read more.
Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. It also mitigated liver function damage and hepatic steatosis. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. In addition, it significantly reversed HFD-induced gut microbiota imbalances. Adzuki bean significantly reduced the ratio of Firmicutes/Bacteroidetes (F/B); enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium; and returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine; and LPS biosynthesis; and valine, leucine, and isoleucine degradation. Full article
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