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Dr. Valentina Giorgio

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Guest Editor

Department of Life Sciences and Global Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Interests: pediatric gastroenterology; pediatric nutrition; pediatric functional gastrointestinal disorders; pediatric inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It has been established that the colonization of the gut in early infancy may have long-term health effects. The goal of this Special Issue, “Diet and Nutritional Intervention for the Infant Gut Microbiome II”, is to focus on the importance of nutrition as a major driver of gut microbiome composition, diversity, and functional capacity.

Given the dynamic development of the gut microbiome in infants and children, the aim of this Special Issue is to clarify if diet and nutritional interventions can influence gut microbiota, favoring overall health and preventing diseases.

Considering the success of the previous Special Issue, "Diet and Nutritional Intervention for the Infant Gut Microbiome ", we are pleased to announce that we are launching a second Special Issue on this topic. This Special Issue on “Diet and Nutritional Intervention for the Infant Gut Microbiome II” will continue to provide healthcare professionals with clear and updated evidence on the modulation of intestinal gut microbiota in pediatrics based on diet and nutritional schemes.

Dr. Valentina Giorgio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

diet
gut microbiota
infants
breastfeeding
nutrition

Published Papers (2 papers)

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Research

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23 pages, 5057 KiB

Open AccessArticle

Seeding the Infant Gut in Early Life—Effects of Maternal and Infant Seeding with Probiotics on Strain Transfer, Microbiota, and Gastrointestinal Symptoms in Healthy Breastfed Infants

by Cathrine Melsaether, Diana Høtoft, Anja Wellejus, Gerben D. A. Hermes and Anders Damholt

Nutrients 2023, 15(18), 4000; https://0-doi-org.brum.beds.ac.uk/10.3390/nu15184000 - 15 Sep 2023

Viewed by 2738

Abstract

We investigated the effects of two dosing regimens of two multi-strain probiotic products on the gut microbiota of breastfed infants, including the transfer of the dosed strains and clinical outcomes. In forty-seven dyads, infants were either exposed through maternal intake (MS) of Lactobacillus acidophilus LA-5, Bifidobacterium animalis subsp. lactis BB-12, Lacticaseibacillus rhamnosus LGG, and Bifidobacterium longum subsp. infantis Bifin02 from gestational week thirty-three until four weeks after birth (n = 24) or dosed directly (IS) with the same strains except for LA-5 starting within 24 h after birth until day 28 (n = 23). Infant stool samples were collected on day 0, 14, 28, and 42 after birth. Gastrointestinal symptoms were assessed by parents using an electronic diary. Microbiota composition was determined using 16S rRNA sequencing, and strain recovery was analyzed by qPCR. Notably, 100% of the IS infants were colonized with Bifin02 after 14 days as opposed to only 25% of the MS infants. Mean stool frequency was significantly lower in IS infants compared to MS infants and IS infants had softer stools on day 14, 28, and 42. A significantly steeper slope of progression of inconsolable crying and fussing was observed in MS infants compared to IS infants. In conclusion, direct infant seeding induced a faster increase in fecal bifidobacteria abundancy and Bifin02 recovery compared to dosed through the maternal intake. Full article

(This article belongs to the Special Issue Diet and Nutritional Intervention for the Infant Gut Microbiome—2nd Edition)

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Review

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24 pages, 1027 KiB

Open AccessReview

The Role of Diet and Nutritional Interventions for the Infant Gut Microbiome

by Giulia Catassi, Marina Aloi, Valentina Giorgio, Antonio Gasbarrini, Giovanni Cammarota and Gianluca Ianiro

Nutrients 2024, 16(3), 400; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16030400 - 30 Jan 2024

Viewed by 2331

Abstract

The infant gut microbiome plays a key role in the healthy development of the human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy and infant nutrition significantly influence the infant gut microbiota. Moreover, breastfeeding fosters the proliferation of beneficial bacteria, while formula feeding increases microbial diversity. The timing of introducing solid foods also influences gut microbiota composition. In preterm infants the gut microbiota development is influenced by multiple factors, including the time since birth and the intake of breast milk, and interventions such as probiotics and prebiotics supplementation show promising results in reducing morbidity and mortality in this population. These findings underscore the need for future research to understand the long-term health impacts of these interventions and for further strategies to enrich the gut microbiome of formula-fed and preterm infants. Full article

(This article belongs to the Special Issue Diet and Nutritional Intervention for the Infant Gut Microbiome—2nd Edition)

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