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The Effect of Collagen Consumption on Human Health

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A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Proteins and Amino Acids".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 20145

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Special Issue Editor

Prof. Dr. Daniel König

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Guest Editor

1. Department for Nutrition, Section for Nutrition, Exercise and Health, Faculty of Life Sciences, University of Vienna, Vienna, Austria
2. Department for Sports Science, Section for Nutrition, Exercise and Health, Centre for Sports Science and University Sports, University of Vienna, Vienna, Austria
Interests: exercise; nutrition; aging; collagen peptides; osteoporosis; sarcopenia; osteoarthritis
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Special Issue Information

Dear Colleagues,

For years, our knowledge of the beneficial health effects of collagen peptides has been constantly increasing. These effects have been demonstrated in vitro as well as in experimental studies in both animals and humans. They range from a reduction in oxidative stress, anti- inflammatory properties, and improvement of wound healing, to positive influences on ageing processes in bones, joints, skin, and muscles. The results so far indicate that collagen peptides may enhance muscle mass in younger subjects but also in elderly persons with sarcopenia, improve bone mineral density in postmenopausal women with osteopenia or osteoporosis, improve joint pain and osteoarthritis, and may reduce cellulite and skin wrinkles.

However, there are still many unresolved questions, in particular with respect to the specific effect of different types of collagen, processes of absorption, and the exact mechanisms of action. The aim of this Special Issue is to bring together recent research on these topics. Submissions of original papers, reviews, meta-analyses, and commentaries on any of the many aspects of collagen peptides and human health are welcome.

Prof. Dr. Daniel König
Guest Editor

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Keywords

Collagen peptides
Inflammation
Osteoarthritis
Functional joint discomfort
Oxidative stress
Skin
Wound healing
Muscle
Sarcopenia
Osteoporosis

Published Papers (2 papers)

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Research

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13 pages, 999 KiB

Open AccessArticle

The Influence of Specific Bioactive Collagen Peptides on Knee Joint Discomfort in Young Physically Active Adults: A Randomized Controlled Trial

by Denise Zdzieblik, Judith Brame, Steffen Oesser, Albert Gollhofer and Daniel König

Nutrients 2021, 13(2), 523; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13020523 - 05 Feb 2021

Cited by 11 | Viewed by 13859

Abstract

First evidence indicates that the supplementation of specific collagen peptides is associated with a significant reduction in activity-related joint pain in young adults. The purpose of the current investigation was to confirm the efficacy of the same collagen peptides in a comparable study population. In total, 180 active men and women aged between 18 and 30 years with exercise-related knee pain but no diagnosed joint disease completed the trial over a period of 12 weeks. Participants were randomly assigned to the group receiving 5 g of specific collagen peptides (CP-G) or to the placebo group (P-G). For the primary outcome, changes in pain during or after exercise from pre- to post-intervention were assessed by the participants using the Visual Analog Scale (VAS). These changes were additionally evaluated by the examining physician by means of anamnesis and physical examination of the affected knee joint. As secondary outcomes, pain under resting conditions and after 20 squats were compared between the study groups. In addition, the mobility of the knee joint and the use of alternative therapies (e.g., ointments or physiotherapy) were recorded. The supplementation of specific collagen peptides derived from type I collagen with a mean molecular weight of 3 kDa led to a significantly (p = 0.024) higher reduction of exercise-induced knee pain (−21.9 ± 18.3 mm) compared with the placebo group (−15.6 ± 18.5 mm). These findings were consistent with the physician’s evaluation (−23.0 ± 19.2 mm vs. −14.6 ± 17.9 mm, p = 0.003). The decrease in pain under resting conditions and after squats did not significantly differ between the groups, as only a small number of participants suffered from pain under these conditions. Due to the clinically unremarkable baseline values, the mobility of the knee joint did not change significantly after the intervention. In conclusion, the current investigation confirmed that the oral intake of bioactive collagen peptides used in the current investigation led to a statistically significant reduction of activity-related joint pain in young active adults suffering from knee joint discomfort. Full article

(This article belongs to the Special Issue The Effect of Collagen Consumption on Human Health)

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Review

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9 pages, 855 KiB

Open AccessReview

Relationship between the Gut Microbiome and Osteoarthritis Pain: Review of the Literature

by Eleuterio A. Sánchez Romero, Erika Meléndez Oliva, José Luis Alonso Pérez, Sebastián Martín Pérez, Silvia Turroni, Lorenzo Marchese and Jorge Hugo Villafañe

Nutrients 2021, 13(3), 716; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13030716 - 24 Feb 2021

Cited by 40 | Viewed by 5557

Abstract

Background: Osteoarthritis (OA) is the most common form of chronic pain in Europe (34%), representing a great economic and social cost to society. There are studies that suggest an intestine–brain–articulation axis and hint at the existence of low-grade intestinal inflammation in OA, which would be related to an alteration of the microbiota and to the impairment of the epithelial barrier, with leakage of the microbial components. Purpose: The purpose of this study was to review the association between gut microbiome and pain in the OA population through a review of the literature. Methods: A literature search was conducted to identify all available studies on the association between the gut microbiome and pain in the OA population, with no publication date limit until September 2020 and no language limit, in the MEDLINE, CINAHL, Web of Science and Cochrane Central Register of Controlled Trials databases. Results: Only three of 2084 studies detected and analyzed by performing the proposed searches in the detailed databases, were finally selected for this review, of which one was with and two were without intervention. These studies only weakly support a relationship between the gut microbiome and OA, specifically a correlation between certain taxa or microbial products and the inflammatory landscape and severity of OA symptoms, including knee pain. Conclusions: Despite encouraging results, this review highlights the paucity of high-quality studies addressing the potential role of the gut microbiome in OA-related pain, along with the disparity of the techniques used so far, making it impossible to draw firm conclusions on the topic. Full article

(This article belongs to the Special Issue The Effect of Collagen Consumption on Human Health)

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