Mechanism and Regulation of Antibiotic Synthesis in Streptomyces
A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".
Deadline for manuscript submissions: closed (31 July 2019) | Viewed by 41038
Special Issue Editor
Interests: Streptomyces; antibiotic; actinomycin; RNA decay; tRNA nucleotidyltransferase; polynucleotide phosphorylase; (p)ppGpp
Special Issue Information
Dear Colleagues,
Nearly two-thirds of all the antibiotics used in clinical and veterinary medicine are synthesized as natural products by members of the bacterial genus Streptomyces. While the mechanism and regulation of antibiotic synthesis in these organisms have been the subjects of extensive study, there are many details of these processes that remain to be elucidated. For example, the relationships between the various regulatory systems that modulate antibiotic production, transcriptional activators and repressors, RNA polymerase sigma factors, butyrolactones, highly phosphorylated guanine nucleotides, to name a few, have yet to be fully clarified.
In this Special Issue, reviews and original research papers will explore various aspects of the control and biosynthesis of antibiotics in Streptomyces.
Prof. Dr. George H. Jones
Guest Editor
Manuscript Submission Information
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Keywords
- Streptomyces
- antibiotic
- biosynthesis
- regulation
- biosynthetic pathway
- secondary metabolism
- signaling