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Role and Application of Stem Cells in Regenerative Medicine (Volume 4)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 5018

Special Issue Editors

Prof. Dr. Oriana Trubiani

E-Mail Website
Guest Editor
Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio”, Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy
Interests: stem cells; dentistry; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Francesca Diomede

E-Mail Website
Guest Editor
Department of Innovative Technologies in Clinical Medicine & Dentistry, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: regenerative medicine; stem cells; microfluidics; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals
Dr. Jacopo Pizzicanella

E-Mail Website
Guest Editor
Department of Engeneering and Geology, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: regenerative medicine; stem cells; oral stem cells; restorative dentistry; osteoregeneration; biomaterials; epithelial–mesenchymal transition; extracellular vesicles; exosomes; liposomes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the fourth version of our previous Special Issue "Role and Application of Stem Cells in Regenerative Medicine”.

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/stem_cells_med

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/stem_cells_med2

https://0-www-mdpi-com.brum.beds.ac.uk/journal/ijms/special_issues/stem_cells_med3

Mesenchymal stem cells (MSCs) are currently being used in preclinical and clinical trials for their ability to promote wound healing and tissue regeneration.

In particular, oral-derived mesenchymal stem cells (oral-MSCs) are accessible and can be collected and used in regenerative medicine, avoiding ethical concerns. They can be derived from different oral tissues, such as human exfoliated deciduous teeth (SHED), periodontal ligaments (PDLSCs), dental follicles (as progenitor (P) cells, DFPCs), apical papilla (SCAP), dental pulp (DPSCs), and gingival tissue (GMSCs), and possess multipotential properties and high proliferation and differentiation abilities. Moreover, oral MSCs have paracrine and immunomodulatory capacity, representing an innovative tool for the treatment of various degenerative and traumatic processes, including skeletal and maxilla-facial degeneration, trauma or ischemia injuries, and neurodegenerative as well as immune disorders.

This new Special Issue will comprise a selection of research papers and reviews contributing to the evaluation of the aptitude of oral-MSCs in particular and their secretome for tissue regeneration, as a starting point for the fabrication of 3D-living constructs for future clinical applications.

Moreover, in vitro and in vivo studies on the molecular mechanisms involved in tissue regeneration are of interest, since they will provide a possibly important contribution to the development of stem cell-based regeneration strategies and to the identification of key biological regulation processes that remain uncovered.

Prof. Dr. Oriana Trubiani
Dr. Francesca Diomede
Dr. Jacopo Pizzicanella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesenchymal stem cells
  • tissue regeneration
  • regenerative medicine
  • immunomodulatory process

Published Papers (4 papers)

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Editorial

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4 pages, 642 KiB  
Editorial
Emerging Role of Oral Mesenchymal Stem/Stromal Cells and Their Derivates
by Guya Diletta Marconi, Francesca Diomede, Jacopo Pizzicannella and Oriana Trubiani
Int. J. Mol. Sci. 2023, 24(15), 12003; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241512003 - 26 Jul 2023
Viewed by 537
Abstract
Mesenchymal stem/stromal cells (MSCs) have fewer ethical, moral, and safety problems in comparison with embryonic stem cells [...] Full article
(This article belongs to the Special Issue Role and Application of Stem Cells in Regenerative Medicine (Volume 4))
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Research

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16 pages, 1774 KiB  
Article
TMT-Based Quantitative Proteomics Analysis Reveals Differentially Expressed Proteins between Different Sources of hMSCs
by Marie Naudot, Julie Le Ber and Paulo Marcelo
Int. J. Mol. Sci. 2023, 24(17), 13544; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241713544 - 31 Aug 2023
Viewed by 856
Abstract
Mesenchymal stem cells (MSCs) are an attractive therapeutic tool for tissue engineering and regenerative medicine owing to their regenerative and trophic properties. The best-known and most widely used are bone marrow MSCs, which are currently being harvested and developed from a wide range [...] Read more.
Mesenchymal stem cells (MSCs) are an attractive therapeutic tool for tissue engineering and regenerative medicine owing to their regenerative and trophic properties. The best-known and most widely used are bone marrow MSCs, which are currently being harvested and developed from a wide range of adult and perinatal tissues. MSCs from different sources are believed to have different secretion potentials and production, which may influence their therapeutic effects. To confirm this, we performed a quantitative proteomic analysis based on the TMT technique of MSCs from three different sources: Wharton’s jelly (WJ), dental pulp (DP), and bone marrow (BM). Our analysis focused on MSC biological properties of interest for tissue engineering. We identified a total of 611 differentially expressed human proteins. WJ-MSCs showed the greatest variation compared with the other sources. WJ produced more extracellular matrix (ECM) proteins and ECM-affiliated proteins and proteins related to the inflammatory and immune response processes. BM-MSCs expressed more proteins involved in osteogenic, adipogenic, neuronal, or muscular differentiation and proteins involved in paracrine communication. Compared to the other sources, DP-MSCs overexpressed proteins involved in the exocytosis process. The results obtained confirm the existence of differences between WJ, DP, and BM-MSCs and the need to select the MSC origin according to the therapeutic objective sought. Full article
(This article belongs to the Special Issue Role and Application of Stem Cells in Regenerative Medicine (Volume 4))
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23 pages, 6452 KiB  
Article
Enriched Graphene Oxide-Polypropylene Suture Threads Buttons Modulate the Inflammatory Pathway Induced by Escherichia coli Lipopolysaccharide
by Luigia Fonticoli, Francesca Diomede, Antonio Nanci, Antonella Fontana, Ylenia Della Rocca, Dainelys Guadarrama Bello, Serena Pilato, Oriana Trubiani, Jacopo Pizzicannella and Guya Diletta Marconi
Int. J. Mol. Sci. 2023, 24(7), 6622; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms24076622 - 01 Apr 2023
Cited by 2 | Viewed by 1545
Abstract
Graphene oxide (GO), derived from graphene, has remarkable chemical–physical properties such as stability, strength, and thermal or electric conductivity and additionally shows antibacterial and anti-inflammatory properties. The present study aimed to evaluate the anti-inflammatory effects of polypropylene suture threads buttons (PPSTBs), enriched with [...] Read more.
Graphene oxide (GO), derived from graphene, has remarkable chemical–physical properties such as stability, strength, and thermal or electric conductivity and additionally shows antibacterial and anti-inflammatory properties. The present study aimed to evaluate the anti-inflammatory effects of polypropylene suture threads buttons (PPSTBs), enriched with two different concentrations of GO, in the modulation of the inflammatory pathway TLR4/MyD 88/NFκB p65/NLRP3 induced by the Escherichia coli (E. coli) lipopolysaccharide (LPS-E). The gene and the protein expression of inflammatory markers were evaluated in an in vitro model of primary human gingival fibroblasts (hGFs) by real-time PCR, western blotting, and immunofluorescence analysis. Both GO concentrations used in the polypropylene suture threads buttons-GO constructs (PPSTBs-GO) decreased the expression of inflammatory markers in hGFs treated with LPS-E. The hGFs morphology and adhesion on the PPSTBs-GO constructs were also visualized by inverted light microscopy, scanning electron microscopy (SEM), and real-time PCR. Together, these results suggest that enriched PPSTBs-GO modulates the inflammatory process through TLR4/MyD 88/NFκB p65/NLRP3 pathway. Full article
(This article belongs to the Special Issue Role and Application of Stem Cells in Regenerative Medicine (Volume 4))
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Review

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16 pages, 733 KiB  
Review
From Teeth to Therapy: A Review of Therapeutic Potential within the Secretome of Stem Cells from Human Exfoliated Deciduous Teeth
by Nurul Hafizah Mohd Nor, Nur Izzati Mansor, Mohd Izhar Ariff Mohd Kashim, Mohd Helmy Mokhtar and Farah Ayuni Mohd Hatta
Int. J. Mol. Sci. 2023, 24(14), 11763; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms241411763 - 21 Jul 2023
Viewed by 1691
Abstract
Stem cells derived from human exfoliated deciduous teeth (SHED) have emerged as an alternative stem cell source for cell therapy and regenerative medicine because they are readily available, pose fewer ethical concerns, and have low immunogenicity and tumourigenicity. SHED offer a number of [...] Read more.
Stem cells derived from human exfoliated deciduous teeth (SHED) have emerged as an alternative stem cell source for cell therapy and regenerative medicine because they are readily available, pose fewer ethical concerns, and have low immunogenicity and tumourigenicity. SHED offer a number of advantages over other dental stem cells, including a high proliferation rate with the potential to differentiate into multiple developmental lineages. The therapeutic effects of SHED are mediated by multiple mechanisms, including immunomodulation, angiogenesis, neurogenesis, osteogenesis, and adipogenesis. In recent years, there is ample evidence that the mechanism of action of SHED is mainly due to its paracrine action, releasing a wide range of soluble factors such as cytokines, chemokines, and trophic factors (also known as ‘secretome’) into the local tissue microenvironment to promote tissue survival and recovery. This review provides an overview of the secretome derived from SHED and highlights the bioactive molecules involved in tissue regeneration and their potential applications in regenerative medicine. Full article
(This article belongs to the Special Issue Role and Application of Stem Cells in Regenerative Medicine (Volume 4))
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