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Special Issue "Molecular Mechanisms Related to Burns, Burn Wound Healing and Scarring 2.0"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 November 2021.

Special Issue Editors

Prof. Dr. Marc Jeschke
E-Mail Website
Guest Editor
Sunnybrook Hlth Sci Ctr, Ross Tilley Burn Ctr, 2075 Bayview Ave, Univ Toronto, Toronto, ON M4N 3M5, Canada
Interests: burn; trauma; stress response; inflammation; hypermetabolism, including insulin resistance; cell regeneration; gene transfer; stem cells
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Lars-Peter Kamolz
E-Mail Website
Guest Editor
Department of Surgery, Medizinische Universität Graz, Graz, Austria
Interests: inflammation; wound healing; fibrosis; tissue regeneration; ageing; immunity; antioxidants; obesity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Burn injury is a complex traumatic event with various local, regional and systemic effects. The pathophysiology of the burn patient shows the full spectrum of the complexity of inflammatory response reactions. In the acute phase, the inflammation mechanism may have negative effects because of capillary leak, the propagation of inhalation injury, and the development of multiple organ failure. Attempts to mediate these processes remain a central subject of burn care-related research. Conversely, inflammation is a necessary component in the later-stage processes of wound healing. Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now, up to 70% of patients develop hypertrophic scars after burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. Approaches to optimizing the healing potential of burn wounds use targeted wound care and surgery to minimize the development of hypertrophic scarring. Such approaches often fail, and modulation of the established scar is continued, although the optimal indication, timing, and combination of therapies have yet to be established. The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimization of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventive and therapeutic strategies. In this issue of the journal, we are looking for articles which deliver a profound insight into the current science of burn wound pathophysiology, burn wound healing, and scarring.

Prof. Dr. Marc Jeschke
Prof. Dr. Lars-Peter Kamolz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • burn injury
  • wound healing
  • scarring
  • pathophysiology
  • molecular mechanism

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Published Papers (1 paper)

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Clostridium Collagenase Impact on Zone of Stasis Stabilization and Transition to Healthy Tissue in Burns
Int. J. Mol. Sci. 2021, 22(16), 8643; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms22168643 - 11 Aug 2021
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Clostridium collagenase has provided superior clinical results in achieving digestion of immediate and accumulating devitalized collagen tissue. Recent studies suggest that debridement via Clostridium collagenase modulates a cellular response to foster an anti-inflammatory microenvironment milieu, allowing for a more coordinated healing response. In [...] Read more.
Clostridium collagenase has provided superior clinical results in achieving digestion of immediate and accumulating devitalized collagen tissue. Recent studies suggest that debridement via Clostridium collagenase modulates a cellular response to foster an anti-inflammatory microenvironment milieu, allowing for a more coordinated healing response. In an effort to better understand its role in burn wounds, we evaluated Clostridium collagenase’s ability to effectively minimize burn progression using the classic burn comb model in pigs. Following burn injury, wounds were treated with Clostridium collagenase or control vehicle daily and biopsied at various time points. Biopsies were evaluated for factors associated with progressing necrosis as well as inflammatory response associated with treatment. Data presented herein showed that Clostridium collagenase treatment prevented destruction of dermal collagen. Additionally, treatment with collagenase reduced necrosis (HMGB1) and apoptosis (CC3a) early in burn injuries, allowing for increased infiltration of cells and protecting tissue from conversion. Furthermore, early epidermal separation and epidermal loss with a clearly defined basement membrane was observed in the treated wounds. We also show that collagenase treatment provided an early and improved inflammatory response followed by faster resolution in neutrophils. In assessing the inflammatory response, collagenase-treated wounds exhibited significantly greater neutrophil influx at day 1, with macrophage recruitment throughout days 2 and 4. In further evaluation, macrophage polarization to MHC II and vascular network maintenance were significantly increased in collagenase-treated wounds, indicative of a pro-resolving macrophage environment. Taken together, these data validate the impact of clostridial collagenases in the pathophysiology of burn wounds and that they complement patient outcomes in the clinical scenario. Full article
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