Special Issue "Molecular Mechanisms Involved in Diabetic Nephropathy"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2020).
Interests: pathophysiology of renal damage; acute kidney injury and chronic kidney disease
Special Issues and Collections in MDPI journals
Diabetic Nephropathy (DN) is a major microvascular complication of diabetes. The epidemic increase of type 2 diabetes is the main cause of chronic kidney disease (CKD) worldwide, leading to premature death and end-stage renal disease (ESRD). Management of DN focuses on the intensive glycemic control and treatment of hypertension, mainly by inhibition of the renin–angiotensin–aldosterone system that delays the onset and progression of DN but does not reduce the risk of ESRD in many patients. During the last few years, tremendous advances have been made concerning the cellular and molecular mechanisms involved in kidney damage during the diabetic process. Although new antidiabetic drugs possess markedly cardiovascular and renal protective effects, it is necessary to increase the knowledge of the molecular mechanisms involved in this pathology to develop novel therapies.
This Special Issue on “Molecular mechanisms involved in Diabetic Nephropathy” will include papers investigating the pathological mechanisms involved in diabetic nephropathy, and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies and clinical studies examining potential new approaches to attenuate kidney dysfunction are welcome.
This Special Issue welcomes original research and review papers. Potential topics include but are not limited to the topics suggested by the keywords below.
Prof. Dr. Jesus Egido
Prof. Dr. Carmen Gómez-Guerrero
Dr. Juan Antonio Moreno Gutierrez
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Experimental models of diabetic nephropathy
- Oxidative stress and inflammation
- NLRP inflammasome
- Cytokines, adipokines, chemokines, and interleukins
- Mitochondrial dysfunction
- Cell signaling
- Autophagy and Senescence
- Gut microbiome
- System Biology, proteomics and miRNAs
- Systemic and urinary biomarkers
- Podocyte dysfunction
- Epithelial to mesenchymal transition in DN
- Flavonoids and herbal medicine
- Novel therapeutic approaches