Special Issue "hCG—An Endocrine, Regulator of Gestation and Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2017).
Interests: hCG; placenta; reproductive immunology; gynecologic oncology; glycoproteins
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Human chorionic gonadotropin is a pregnancy hormone and, in addition, a complex glycoprotein with a molecular mass of about 37 kDa. It is composed of two glycosylated subunits, which are associated non-covalently. It is produced in the placental syncytiotrophoblast and in a large number of different tumours. Like the pituitary gonadotropins LH (luteinizing hormone), FSH (follicle-stimulating hormone) and TSH (thyroid-stimulating hormone), it is a heterodimer and composed of an alpha-subunit, which is common for the glycoprotein family and a specific β-subunit. There are five major isoforms of hCG: 1: hCG, 2: sulfated hCG, 3: hyperglycosylated hCG, 4: hCG free β-subunit and 5: hyperglycosylated hCG free β-subunit. The most often described function of hCG is its role in pregnancy. Human chorionic gonadotropin is the essential hormone to maintain pregnancy. It controls the implantation and the development of the placenta. It also controls the transformation of the corpus luteum to gravid corpus, which, in turn, obtains the production of progesterone and estradiol in the first weeks of pregnancy. On the other hand, there are several types of malignancies including bladder carcinoma, lung cancer, colorectal carcinoma, prostate cancer, gastric carcinomas and different gynecological cancers like breast cancer, cervical carcinoma, vulva/vaginal cancer which express hCG or its subunits ectopically. Therefore this special issue will deal on this entire different expression pattern and will also deal with functional aspects of hCG.
Prof. Dr. Udo Jeschke
Manuscript Submission Information
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- disturbed pregnancy
- G-Protein coupled receptor pathways