Special Issue "hCG—An Endocrine, Regulator of Gestation and Cancer"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2017).
Interests: hCG; placenta; reproductive immunology; gynecologic oncology; glycoproteins
Special Issues and Collections in MDPI journals
Special Issue in Journal of Clinical Medicine: Molecular Biology of Ovarian Cancer
Special Issue in International Journal of Molecular Sciences: Reproductive Immunology: Cellular and Molecular Biology 2.0
Human chorionic gonadotropin is a pregnancy hormone and, in addition, a complex glycoprotein with a molecular mass of about 37 kDa. It is composed of two glycosylated subunits, which are associated non-covalently. It is produced in the placental syncytiotrophoblast and in a large number of different tumours. Like the pituitary gonadotropins LH (luteinizing hormone), FSH (follicle-stimulating hormone) and TSH (thyroid-stimulating hormone), it is a heterodimer and composed of an alpha-subunit, which is common for the glycoprotein family and a specific β-subunit. There are five major isoforms of hCG: 1: hCG, 2: sulfated hCG, 3: hyperglycosylated hCG, 4: hCG free β-subunit and 5: hyperglycosylated hCG free β-subunit. The most often described function of hCG is its role in pregnancy. Human chorionic gonadotropin is the essential hormone to maintain pregnancy. It controls the implantation and the development of the placenta. It also controls the transformation of the corpus luteum to gravid corpus, which, in turn, obtains the production of progesterone and estradiol in the first weeks of pregnancy. On the other hand, there are several types of malignancies including bladder carcinoma, lung cancer, colorectal carcinoma, prostate cancer, gastric carcinomas and different gynecological cancers like breast cancer, cervical carcinoma, vulva/vaginal cancer which express hCG or its subunits ectopically. Therefore this special issue will deal on this entire different expression pattern and will also deal with functional aspects of hCG.
Prof. Dr. Udo Jeschke
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- disturbed pregnancy
- G-Protein coupled receptor pathways