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Nutrients
Special Issues
Prebiotics, Probiotics and Nutrition Effects on the Human Metabolome
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Prebiotics, Probiotics and Nutrition Effects on the Human Metabolome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 5459

Special Issue Editors

Dr. Emidio Scarpellini

E-Mail Website
Guest Editor
Internal Medicine, Sapienza University of Rome, 5, 00185 Roma, Italy
Interests: gut microbiota; pathophysiology; functional gastrointestinal disorders; antibiotics; probiotics
Special Issues, Collections and Topics in MDPI journals
Dr. Emanuele Rinninella

E-Mail Website
Guest Editor
1. Research and Training Center in Human Nutrition, Catholic University of Sacred Heart, 00168 Rome, Italy
2. Clinical Nutrition Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Rome, Italy
Interests: clinical nutrition; perioperative nutrition; body composition; gut microbiota dietary modulation; digestive cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last 40 years, gut microbiota composition, primarily, and, therefore, functioning are subjects upon which the energy and attention of scientists from different specializations have been focused. Metabolites produced from human gut microbiota strictly interact and meld with those of the host. This metabolic “jam session” has been implicated in the pathogenesis of metabolic and non-metabolic conditions affecting the human host. Eminent examples include obesity, microinflammation, diabetes, cardiovascular disorders, non-alcoholic liver disease, liver cirrhosis and cancers.

We aim to involve authors via their contributions in the field of gut microbiota composition and the concept, physiology, pathophysiology and clinical manifestations of the human metabolome.

Newer data on gut microbiota composition and functions, the concept of the human gut metabolome and their interactions in health and disease will enrich the research panorama, giving vital fuel to researchers from medical, biomedical and bio-engineering fields of interest. We are soliciting original contributions in addition to narratives and/or systematic reviews and metanalyses of the literature.

Dr. Emidio Scarpellini
Dr. Emanuele Rinninella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • metabolism
  • metabolomics
  • metabolism dysfunction
  • obesity

Published Papers (3 papers)

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Research

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19 pages, 1569 KiB  
Article
A 12-Week, Single-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Design Clinical Trial for the Evaluation of the Efficacy and Safety of Lactiplantibacillus plantarum SKO-001 in Reducing Body Fat
by Seon Mi Shin, Jeong-Su Park, Sang Back Kim, Young Hee Cho, Hee Seo and Hak Sung Lee
Nutrients 2024, 16(8), 1137; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16081137 - 11 Apr 2024
Viewed by 966
Abstract
There is growing evidence linking gut microbiota to overall health, including obesity risk and associated diseases. Lactiplantibacillus plantarum SKO-001, a probiotic strain isolated from Angelica gigas, has been reported to reduce obesity by controlling the gut microbiome. In this double-blind, randomised clinical [...] Read more.
There is growing evidence linking gut microbiota to overall health, including obesity risk and associated diseases. Lactiplantibacillus plantarum SKO-001, a probiotic strain isolated from Angelica gigas, has been reported to reduce obesity by controlling the gut microbiome. In this double-blind, randomised clinical trial, we aimed to evaluate the efficacy and safety of SKO-001 in reducing body fat. We included 100 participants randomised into SKO-001 or placebo groups (1:1) for 12 weeks. Dual-energy X-ray absorptiometry was used to objectively evaluate body fat reduction. Body fat percentage (p = 0.016), body fat mass (p = 0.02), low-density lipoprotein-cholesterol levels (p = 0.025), and adiponectin levels (p = 0.023) were lower in the SKO-001 group than in the placebo group after 12 weeks of SKO-001 consumption. In the SKO-001 group, the subcutaneous fat area (p = 0.003), total cholesterol levels (p = 0.003), and leptin levels (p = 0.014) significantly decreased after 12 weeks of SKO-001 consumption compared with baseline values. Additionally, SKO-001 did not cause any severe adverse reactions. In conclusion, SKO-001 is safe and effective for reducing body fat and has the potential for further clinical testing in humans. Full article
(This article belongs to the Special Issue Prebiotics, Probiotics and Nutrition Effects on the Human Metabolome)
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13 pages, 1405 KiB  
Article
Gut Microbiota in Patients with Prediabetes
by Wei-Lin Chang, Yu-En Chen, Hsiang-Tung Tseng, Ching-Feng Cheng, Jing-Hui Wu and Yi-Cheng Hou
Nutrients 2024, 16(8), 1105; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16081105 - 09 Apr 2024
Viewed by 981
Abstract
Prediabetes is characterized by abnormal glycemic levels below the type 2 diabetes threshold, and effective control of blood glucose may prevent the progression to type 2 diabetes. While the association between the gut microbiota, glucose metabolism, and insulin resistance in diabetic patients has [...] Read more.
Prediabetes is characterized by abnormal glycemic levels below the type 2 diabetes threshold, and effective control of blood glucose may prevent the progression to type 2 diabetes. While the association between the gut microbiota, glucose metabolism, and insulin resistance in diabetic patients has been established in previous studies, there is a lack of research regarding these aspects in prediabetic patients in Asia. We aim to investigate the composition of the gut microbiota in prediabetic patients and their differences compared to healthy individuals. In total, 57 prediabetic patients and 60 healthy adult individuals aged 18 to 65 years old were included in this study. Biochemistry data, fecal samples, and 3 days of food records were collected. Deoxyribonucleic acid extraction and next-generation sequencing via 16S ribosomal ribonucleic acid metagenomic sequencing were conducted to analyze the relationship between the gut microbiota and dietary habits. Prediabetic patients showed a lower microbial diversity than healthy individuals, with 9 bacterial genera being less abundant and 14 others more abundant. Prediabetic patients who consumed a low-carbohydrate (LC) diet exhibited higher diversity in the gut microbiota than those who consumed a high-carbohydrate diet. A higher abundance of Coprococcus was observed in the prediabetic patients on an LC diet. Compared to healthy individuals, the gut microbiota of prediabetic patients was significantly different, and adopting an LC diet with high dietary fiber consumption may positively impact the gut microbiota. Future studies should aim to understand the relationship between the gut microbiota and glycemic control in the Asian population. Full article
(This article belongs to the Special Issue Prebiotics, Probiotics and Nutrition Effects on the Human Metabolome)
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Review

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20 pages, 962 KiB  
Review
The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy
by Remo Poto, William Fusco, Emanuele Rinninella, Marco Cintoni, Francesco Kaitsas, Pauline Raoul, Cristiano Caruso, Maria Cristina Mele, Gilda Varricchi, Antonio Gasbarrini, Giovanni Cammarota and Gianluca Ianiro
Nutrients 2024, 16(1), 92; https://0-doi-org.brum.beds.ac.uk/10.3390/nu16010092 - 27 Dec 2023
Cited by 1 | Viewed by 3107
Abstract
Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and the integrity of our intestinal barrier may play roles in the development of FA. Environmental factors, [...] Read more.
Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and the integrity of our intestinal barrier may play roles in the development of FA. Environmental factors, including industrialization and consumption of highly processed food, can contribute to altering the gut microbiota and the intestinal barrier, increasing the susceptibility to allergic sensitization. Compositional and functional alterations to the gut microbiome have also been associated with FA. In addition, increased permeability of the gut barrier allows the translocation of allergenic molecules, triggering Th2 immune responses. Preclinical and clinical studies have highlighted the potential of probiotics, prebiotics, and postbiotics in the prevention and treatment of FA through enhancing gut barrier function and promoting the restoration of healthy gut microbiota. Finally, fecal microbiota transplantation (FMT) is now being explored as a promising therapeutic strategy to prevent FA in both experimental and clinical studies. In this review article, we aim to explore the complex interplay between intestinal permeability and gut microbiota in the development of FA, as well as depict potential therapeutic strategies. Full article
(This article belongs to the Special Issue Prebiotics, Probiotics and Nutrition Effects on the Human Metabolome)
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