Special Issue "The Role of Triglycerides and Triglyceride Metabolism in Human Health"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. John Mamo
E-Mail Website
Guest Editor
Faculty of Health Sciences, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Bentley, WA 6102, Australia
Interests: lipoprotein metabolism; postprandial lipoproteins; cardiovascular disease; cerebrovascular disease; neurodegenerative disorders
Dr. Ryu Takechi
E-Mail Website
Guest Editor
Faculty of Health Sciences, Curtin Health Innovation Research Institute (CHIRI), Curtin University, Bentley, WA 6102, Australia
Interests: lipoprotein metabolism; triglyceride-rich lipoproteins; cardiovascular disease; neurodegenerative disorders; endocrine disorders
Dr. Virginie Lam
E-Mail Website
Guest Editor
School of Public Health, Faculty of Health Sciences, Curtin University, Bentley, WA 6102, Australia
Interests: lipoprotein metabolism; triglyceride-rich lipoproteins; cardiovascular disease; neurodegenerative disorders; endocrine disorders

Special Issue Information

Dear Colleagues,

There is accumulating evidence that elevated plasma triglyceride levels are a risk factor for cardiovascular and cerebrovascular disorders including stroke, and for metabolic diseases such as diabetes. Aberrations in the metabolism of triglyceride-rich lipoproteins and their remnants are increasingly considered pathogenic, much like low-density lipoprotein, however the mechanisms of causality are less clear.

The Nutrients Special Issue titled “The Role of Triglycerides and Triglyceride Metabolism in Human Health” seeks to provide contemporary consideration of how the metabolism of triglycerides and of triglyceride-rich lipoproteins contributes to human health, especially the etiology of vascular-based disorders. The Special Issue seeks to include, but to also expand knowledge beyond, cardiovascular disease and atherosclerosis. Submissions with a focus on cerebrovascular and neurodegenerative disorders, peripheral vascular disease, as well as metabolic and/or endocrine dysfunction are strongly encouraged.

We hope you find this Special Issue “The Role of Triglycerides and Triglyceride Metabolism in Human Health” to be timely, and appreciate your positive consideration to submit.

Prof. Dr. John Mamo 
Dr. Ryu Takechi
Dr. Virginie Lam
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Triglycerides
  • Triglyceride-rich lipoproteins
  • Vascular disease
  • Metabolic health

Published Papers (4 papers)

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Research

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Article
Predictive Value of the Atherogenic Index of Plasma (AIP) for the Risk of Incident Ischemic Heart Disease among Non-Diabetic Koreans
Nutrients 2021, 13(9), 3231; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13093231 - 16 Sep 2021
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Abstract
The atherogenic index of plasma (AIP), composed of triglycerides and high-density lipoprotein cholesterol, is a novel critical marker for assessing the risk of atherogenicity and cardiometabolic health. We aimed to prospectively study the association between AIP and incident ischemic heart disease (IHD) risk [...] Read more.
The atherogenic index of plasma (AIP), composed of triglycerides and high-density lipoprotein cholesterol, is a novel critical marker for assessing the risk of atherogenicity and cardiometabolic health. We aimed to prospectively study the association between AIP and incident ischemic heart disease (IHD) risk in a large cohort of non-diabetic Korean adults. Data were assessed from 17,944 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to AIP quartiles, calculated as log (triglyceride/high-density lipoprotein cholesterol). We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazard regression models over a 50-month period that followed the baseline survey. During the follow-up period, 332 participants (1.9%) developed IHD. HRs of IHD for AIP quartiles 2–4 were 1.58 (95% CI, 1.03–2.43), 1.82 (95% CI, 1.20–2.78), and 2.11 (95% CI, 1.37–3.24) after adjusting for age, sex, body mass index, smoking status, alcohol intake, physical activity, mean arterial blood pressure, fasting plasma glucose, high-sensitivity C-reactive protein level, and hypertension medication. Higher AIP levels may precede and predict the development of IHD in non-diabetic Korean adults. Full article
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
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Article
Decreased Efficiency of Very-Low-Density Lipoprotein Lipolysis Is Linked to Both Hypertriglyceridemia and Hypercholesterolemia, but It Can Be Counteracted by High-Density Lipoprotein
Nutrients 2021, 13(4), 1224; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13041224 - 08 Apr 2021
Viewed by 770
Abstract
Impaired triglyceride-rich lipoprotein plasma catabolism is considered the most important factor for hypertriglyceridemia development. The aim of this study was to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL)-triglyceride lipolysis and the role of [...] Read more.
Impaired triglyceride-rich lipoprotein plasma catabolism is considered the most important factor for hypertriglyceridemia development. The aim of this study was to evaluate the impact of hypercholesterolemia and hypertriglyceridemia on the efficiency of lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL)-triglyceride lipolysis and the role of high-density lipoprotein (HDL) in this process. Subjects with no history of cardiovascular disease (CVD) and untreated with lipid-lowering agents were recruited into the study and divided into normolipidemic, hypercholesterolemic, and hyperlipidemic groups. VLDL was isolated from serum and incubated with LPL in the absence or presence of HDL. For the hypercholesterolemic and hyperlipidemic groups, a significantly lower percentage of hydrolyzed VLDL-triglyceride was achieved compared to the normolipidemic group (p < 0.01). HDL enhanced the lipolysis efficiency in the hypercholesterolemic and hyperlipidemic groups on average by ~7% (p < 0.001). The lowest electrophoretic mobility of the VLDL remnants indicating the most effective lipolysis was obtained in the normolipidemic group (p < 0.05). HDL presence significantly reduced the electrophoretic mobility of the VLDL remnants for the hypercholesterolemic and hyperlipidemic groups (p < 0.05). The results of our study indicate that VLDL obtained from hypercholesterolemic and hyperlipidemic subjects are more resistant to lipolysis and are additional evidence of the need for early implementation of hypocholesterolemic treatment, already in asymptomatic CVD subjects. Full article
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
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Review

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Review
The Role of High Triglycerides Level in Predicting Cognitive Impairment: A Review of Current Evidence
Nutrients 2021, 13(6), 2118; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13062118 - 20 Jun 2021
Cited by 1 | Viewed by 1226
Abstract
The burden of cognitive disorders is huge and still growing, however the etiology and the degree of cognitive impairment vary considerably. Neurodegenerative and vascular mechanisms were most frequently assessed in patients with dementia. Recent studies have shown the possible involvement of triglycerides levels [...] Read more.
The burden of cognitive disorders is huge and still growing, however the etiology and the degree of cognitive impairment vary considerably. Neurodegenerative and vascular mechanisms were most frequently assessed in patients with dementia. Recent studies have shown the possible involvement of triglycerides levels in cognitive function through putative mechanisms such as brain blood barrier dysfunction or amyloid metabolism imbalance, but not all research in the field found this association. Several clinical studies evaluated the relationship between different forms of cognitive decline and levels of serum triglycerides, independent of other cardiovascular risk factors. This review focuses on the role of triglycerides in cognitive decline, cerebral amyloidosis and vascular impairment. Considering that the management of hypertriglyceridemia benefits from lifestyle modification, diet, and specific drug therapy, future studies are requested to appraise the triglycerides–cognitive impairment relationship. Full article
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
Review
Triglyceride-Rich Lipoproteins and Their Remnants as Silent Promoters of Atherosclerotic Cardiovascular Disease and Other Metabolic Disorders: A Review
Nutrients 2021, 13(6), 1774; https://0-doi-org.brum.beds.ac.uk/10.3390/nu13061774 - 22 May 2021
Viewed by 1202
Abstract
While targeting elevated serum levels of low-density lipoprotein cholesterol has been the mainstay of atherosclerosis prevention and treatment for decades, the evidence regarding the atherogenic role of hypertriglyceridemia is still controversial. Various epidemiological population-based studies on statin-treated subjects nominated triglycerides, triglyceride-rich lipoproteins (namely, [...] Read more.
While targeting elevated serum levels of low-density lipoprotein cholesterol has been the mainstay of atherosclerosis prevention and treatment for decades, the evidence regarding the atherogenic role of hypertriglyceridemia is still controversial. Various epidemiological population-based studies on statin-treated subjects nominated triglycerides, triglyceride-rich lipoproteins (namely, chylomicrons and very-low-density lipoprotein particles), and their remnants as major determinants of the substantial residual cardiovascular risk. With the triglyceride-glucose index and triglyceride to high-density lipoprotein ratio emerging as surrogate indicators of peripheral artery disease and atherosclerotic cerebrovascular disease, one can conclude that further research addressing the intricate relationship between triglycerides and atherosclerosis is warranted. Therefore, this review aims to provide insight into the current clinical and epidemiological state of knowledge on the relationship between triglycerides and atherosclerotic cardiovascular disease. It also intends to highlight the connection between triglycerides and other metabolic disorders, including diabetes mellitus, and the potential benefits of triglyceride-lowering agents on cardiovascular outcomes and all-cause mortality. Full article
(This article belongs to the Special Issue The Role of Triglycerides and Triglyceride Metabolism in Human Health)
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