Int. J. Mol. Sci., Volume 22, Issue 7 (April-1 2021) – 512 articles
Cover Story (view full-size image): Alveolar macrophages (AMs) are the most abundant cell type in the bronchioalveolar space. With every breath, the human organism is confronted with a variety of pathogens, particles, or molecules. Here, AMs sense these various invaders and, thus, represent a crucial cell type within innate pulmonary immunity. AMs have been shown to be a highly plastic cell type, able to orchestrate not only pulmonary host response but also to maintain lung tissue homeostasis. Thus, dysfunction and/or impaired development of AMs can lead to various lung diseases, ranging from increased susceptibility to pathogens, congenital lung diseases or progressive lung disorders. Thus, insights into the role of AMs have laid the foundation for new drugs and even macrophage-based immunotherapies. View this paper.
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