Int. J. Environ. Res. Public Health, Volume 17, Issue 16 (August-2 2020) – 382 articles
In this study, glyphosate, thiacloprid, and imidacloprid were tested for their potential binding on two key targets of the endocrine system: aromatase and estrogen receptor. Gyphosate inhibited aromatase activity and decreased estrogen production from androgens. Imidacloprid and thiacloprid bind to the estrogen receptor. All these interactions were partial or occurring at relatively high concentrations. Computational simulations predicted the binding sites and modes of the three pesticides to the two protein targets, providing a molecular model for their action mechanism as EDCs. View this paper.
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