Special Issue "Hedgehog Signaling 2.0"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: cancer biology; cell proliferation; signal transduction; cell differentiation; cell adhesion
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Hedgehog signaling pathways govern complex developmental processes, including stem-cell maintenance, proliferation, differentiation, and patterning. However, hedgehog signaling is frequently activated in various human cancers. Several recent studies have shown that the aberrant activation of hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, the drug resistance of multiple cancers, and survival rate.
Recent evidence indicates that Hedgehog signaling is involved, through different mechanisms, in human malignancies, where it promotes growth, enables the proliferation of tumor stem cells, and regulates the tumor-stroma interaction. A ligand-independent Shh pathway activation has been described in familial cancers, such as basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, as a consequence of genetic aberrations, targeting mainly the Ptch inhibitory receptor. Ligand-independent non-canonical Shh pathway activation has been reported in several tumor models as a result of a crosstalk with different tumorigenic pathways. Finally, ligand-dependent autocrine or paracrine activation has also been described. Research articles, reviews, and communications on every aspect of Hedgehog signaling in development, organogenesis, cancer and other human diseases, as well as on the role of Hedgehog molecules as diagnostic, prognostic, and therapeutic targets are invited.
This Special Issue focuses on several aspects of hedgehog signaling research, and we invite contributions of reviews and/or original papers reporting on the recent efforts in the field of hedgehog signaling.
Prof. Dr. Tsuyoshi Shimo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- tumor micro-environment
- cancer stem cell
- tumor–stroma interaction
- target genes
- primary cilia
- hedgehog signaling pathway
- hedgehog signaling inhibitors
- targeted cancer therapy
- cancer treatment resistance
- immune surveillance